Progress in understanding mitochondrial calcium uniporter complex-mediated calcium signalling: A potential target for cancer treatment
BRITISH JOURNAL OF PHARMACOLOGY
Authors: Cui, Chaochu; Yang, Jianbo; Fu, Liwu; Wang, Mingyong; Wang, Xianwei
Abstract
Due to its Ca2+ buffering capacity, the mitochondrion is one of the most important intracellular organelles in regulating Ca2+ dynamic oscillation. Mitochondrial calcium uniporter (MCU) is the primary mediator of Ca2+ influx into mitochondria, manipulating cell energy metabolism, ROS production, and programmed cell death, all of which are critical for carcinogenesis. The understanding of the uniporter complex was significantly boosted by recent groundbreaking discoveries that identified the uniporter pore-forming subunit MCU and its regulatory molecules, including MCU-dominant negative beta subunit (MCUb), essential MCU regulator (EMRE), MCU regulator 1 (MCUR1), mitochondrial calcium uptake (MICU) 1, MICU2, and MICU3. These provide the means and molecular platform to investigate MCU complex (uniplex)-mediated impaired Ca2+ signalling in physiology and pathology. This review aims to summarize the progress of the understanding regulatory mechanisms of uniplex, roles of uniplex-mediated Ca2+ signalling in cancer, and potential pharmacological inhibitors of MCU.
A 28nm fully digital voltage monitor with 16.5uV/degrees C accuracy and 0.8mV quantized error from-40 to 160 degrees C for ISO26262 ASIL-D capable MCU
2019 IEEE ASIAN SOLID-STATE CIRCUITS CONFERENCE (A-SSCC)
Authors: Uemura, Toshifumi; Kitaji, Yuko; Fukuoka, Kazuki
Abstract
A fully digital voltage monitoring system has been developed for automotive ISO26262 ASIL-D capable MCUs to detect internal under-voltage fault at IR-drop hotspots and to mitigate large Vmin margin due to voltage detection variation. Proposed oscillators employing temperature coefficient tuners enable digitized voltage detection with small temperature drift and quantized error. A digital voltage monitor fabricated in 28nm shows temperature drift of 16.5uV/degrees C and 0.8mV quantized error. The total voltage detection variation of 4.1mV is the smallest and the temperature range from -40 to 160 degrees C is the largest compared with previous works
COA
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