Specifications
Immunogen
Human recombinant protein fragment corresponding to aa 424-773 of human LAMB3 (NP_000219).
Applications
Application Notes
WB 1:2000; IHC 1:150
Each laboratory should determine an optimum working titer for use in its particular application.
Other applications have not been tested but use in such assays should not necessarily be excluded.
Target
Alternative Names
LAMB3; laminin, beta 3; laminin, beta 3 (nicein (125kD), kalinin (140kD), BM600 (125kD)) , LAMNB1; laminin subunit beta-3; BM600 125kDa; kalinin 140kDa; nicein 125kDa; nicein-125kDa; kalinin-140kDa; kalinin B1 chain; laminin B1k chain; laminin S B3 chain;
Product Background
Pathway
Alpha6-Beta4 Integrin Signaling Pathway; Anchoring fibril formation; Cell junction organization; Collagen formation
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Cserhalmi, PB; Horvath, A; et al. Identification of the LAMB3 hotspot mutation R635X in a Hungarian case of Herlitz junctional epidermolysis bullosa. EXPERIMENTAL DERMATOLOGY 6:70-74(1997).
Spirito, F; Charlesworth, A; et al. Animal models for skin blistering conditions: Absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse. JOURNAL OF INVESTIGATIVE DERMATOLOGY 119:684-691(2002).
COA
Certificate of Analysis
