Creative Diagnostics has proprietary Epitope Mapping platforms for accurate identification and characterization of antigenic epitopes. We offer Epitope Mapping services with state-of-the-art techniques and validated bioanalytical methods for accurate, sensitive, reproducible and stable epitope characterization. Our services are well suited for antibody development, therapeutic monitoring, and vaccine research applications.
Orbitrap Fusion Lumos
Thermo Fisher Scientific Titan Krios
PerkinElmer Sciclone G3
Creative Diagnostics provides Epitope Mapping services to understand the reaction of an antibody with an antigen in a biological system. We provide a turnkey epitope mapping solution based on our experience and know-how in bioanalytical method development, cutting-edge detection technology, and assay optimization. We offer customized epitope mapping systems to meet the different needs of our customers. Our epitope mapping systems allow us to detect and characterize the epitope on the antigen molecule with high sensitivity, specificity, and reproducibility. The systems also enable real-time detection of epitopes, immune response, and their interactions for faster antibody development. We provide:
To meet the need for accurate and reliable analysis in Epitope Mapping, we provide comprehensive Epitope Mapping Services.Based on our high throughput bioanalytical platform, and sensitive detection system, we can specifically and accurately identify and characterize the antigenic epitopes recognized by antibodies. We also provide sample processing optimization, experimental validation, as well as different analysis methods (peptide scanning, SPR, ELISA etc. ), to achieve the best sensitivity, specificity and biological relevance of data. This platform is used extensively for antibody development, vaccine discovery, and therapeutic monitoring purposes. Our standardized quality control and large experience in technology application, give you high reproducibility, stability and data consistency for each project. Our core services include:
We accurately map and characterize key epitopes on antigens using techniques like peptide scanning, X-ray crystallography and surface plasmon resonance (SPR) with high sensitivity and specificity.
We provide a range of epitope mapping technologies, including linear and conformational epitope analysis, combined with immunological methods and biophysical analysis, to help you identify specific antibody binding sites.
We offer a range of customizable services depending upon your needs including epitope mapping analysis of your target antibody/antigen/vaccine for vaccine design and development, antibody engineering and immunotherapy research.
We use high-throughput screening technologies to quickly identify multiple epitopes and also perform large-scale screenings of multiple antigen/antibody pairs to facilitate the discovery of putative immunogenic epitopes.
Monitoring antibody-antigen interactions in real-time allows us to assess the strength and duration of immune responses. This information can be used to optimize antibody design and vaccine development.
We offer comprehensive epitope mapping, affinity measurement, and immunogenicity analysis reports. We apply advanced bioinformatics tools for data analysis and predict antigen surface exposure and immune escape mechanisms.
Through a strict experimental validation process, we optimize experimental conditions and ensure data reproducibility, stability, and reliability, ensuring high-quality research outcomes.
We offer interdisciplinary technical support covering protein engineering, molecular biology, immunology, and biophysics, assisting customers in realizing the complete process from basic research to clinical translation.
Communicate with clients to develop a customized epitope mapping plan.
Select an appropriate epitope mapping technology and prepare samples.
Identify epitopes and evaluate antibody-antigen binding.
Provide data analysis results and detailed reports.
Provide project summaries and follow-up technical support.
This figure is an optimized antibody affinity and specificity by epitope mapping, for the application of cancer immunotherapy. This figure depicts the intensities of immune response of 4 critical epitopes (Epitope 1 to Epitope 4), based on epitopes discovered by epitope mapping, for tumor antigen recognition. The immune response intensities of Epitope 1 to Epitope 4 are 40, 60, 80 and 90 respectively, suggesting that epitopes play a critical role in antibody design optimization and can substantially improve antibody affinity and specificity, with reduced side effects on normal tissues.
Absolutely! Epitope mapping results allow you to find the most important immunogenic regions on an antigen for a focused vaccine development or inducing the most comprehensive immune response.
Turnaround times for our epitope mapping service vary based on project complexity and sample load. Preliminary results are generally available in a few weeks. However, we ensure the high quality and reliability of the data.
To use our epitope mapping services, please contact Creative Diagnostics, your expert immunology service provider. From research-scale epitope mapping services to scale-up, our team is ready to support your R&D innovation.
