Magic™ Rabbit Anti-Human TRIM21 Monoclonal antibody, clone 351502C23

Antibody Isotype

IgG

Clone

351502C23

Species Reactivity

Human

Immunogen

TRIM21 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1215 - DMAB-CPT1216
Cytometric Bead Array: 1.56-100 ng/mL

General Notes

This product (Catalog No. DMAB-CPT1216) is a rabbit-derived monoclonal antibody raised against human TRIM21. It has been affinity purified by Protein A. TRIM21 has multiple N-terminal zinc finger motifs(has E3 ligase activity), a central leucine zipper, and a potential N-glycosylation site. TRIM21 is a E3 ubiquitin-protein ligase. It can form a ubiquitin ligase complex with E2 UBE2D2, which function not only for the uniquitination of USP4 and IKBKB but also for its self-ubiquitination. It has a role in the regulation of the cell cycle progression and could enhance the decapping activity of DCP2. It can exist in all mammalian cells as a ribonucleoprotein particle, which composed of a single polypeptide and 1 of 4 small RNA molecules. TRIM21 exists various isoforms and range molecular weight of isoforms is about 42-45kDa and 49-54 kDa.
DMAB-CPT1216 is suitable for use in Cytometric Bead Array (1.56-100 ng/mL) application.
DMAB-CPT1216 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

52 kDa Ro protein; RING finger protein 81; RNF81; Ro(SS A); RO52; SS A; SSA; SSA1; TRIM21; tripartite motif containing 21

Entrez Gene ID

UniProt ID