Specificity: 4012 can bind to Human and Cynomolgus Monkey IGIT.
Isotype: IgG
Application: ELISA, BL, FC, FuncS
4012 can bind to the TIGIT protein and has a stronger binding affinity than the similar substance of Tiragolumab; it can block the TIGIT/CD155 binding, and the blocking ability is not weaker than that of the similar substance of Tiragolumab; it can bind to 293T-TIGIT; and it can promote the activation of Jurkat T cells. The KD of 4012 is 5.08E-12.
Summary
Specifications
Antibody Isotype
IgG
Clone
4012
Species Reactivity
Human; Cynomolgus
Immunogen
Recombinant TIGIT protein
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in ELISA, BL, FC, FuncS. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Target
Alternative Names
TIGIT; VSIG9; VSTM3; WUCAM; T-cell immunoreceptor with Ig and ITIM domain
Citations
Publication ()
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COA
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