Mouse Anti-Human THPO Monoclonal antibody, clone 9H6

Antibody Isotype

IgG2a

Clone

9H6

Species Reactivity

Human

Immunogen

Recombinant human THPO

Conjugate

Application Notes

We recommend the following antibodies for sandwich ELISA (Capture - Detection):
DMAB-CBAS001 - DMAB-CBAS002

General Notes

This product (Catalog No. DMAB-CBAS002) is a mouse-derived monoclonal antibody raised against human THPO. It has been affinity purified by Protein A. The THPO gene encodes thrombopoietin, a cytokine that is essential for the production and maturation of platelets from megakaryocytes in the bone marrow. Thrombopoietin stimulates megakaryocyte proliferation and differentiation, and its levels are inversely regulated by circulating platelets. Biallelic loss-of-function mutations in THPO cause severe thrombocytopenia and bone marrow failure (congenital amegakaryocytic thrombocytopenia-2, CAMT2). In contrast, monoallelic loss-of-function variants lead to reduced thrombopoietin secretion and autosomal-dominant thrombocytopenia without affecting other blood cell lineages. THPO binds to the MPL receptor on megakaryocytes, promoting their maturation and platelet formation. Genetic mutations in the THPO gene can lead to disorders such as essential thrombocythemia and congenital amegakaryocytic thrombocytopenia.
DMAB-CBAS002 is suitable for use in ELISA(Det) application.
DMAB-CBAS002 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Thrombopoietin; THPO; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1

UniProt ID