Product Overview
Amino Acid Sequence
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVLGG GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKK IETHKLTFRE
Tag/Conjugate
Unconjugated
Bio-activity
Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
Alternative Names
Active tau PFFs; tau PFF; active tau protein Pre-formed Fibrils; active tau aggregates; microtubule-associated protein tau; MAPT; MAP; microtubule-associated protein; Paired Helical Filament-Tau; Phf-Tau; Neurofibrillary Tangle Protein; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Isoform 4; tubulin-associated unit
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
10 mM HEPES, 100 mM NaCl, pH 7.4
Introduction
Tau protein is a highly soluble microtubule-associated protein (MAP) that is abundant in neurons of the central nervous system and relatively poorly expressed in non-neuronal cells (astrocytes, oligodendrocytes, etc.). One of its main functions is to maintain axonal microtubule stability and ensure normal brain function. The neurofibrillary tangles observed in Alzheimer's disease (AD) and other tau lesions are aggregations of paired helical fibrils composed of hyperphosphorylated tau.
Keywords
Alzheimer's Disease; Axon Markers; Cell Markers; Cell Signaling; Cytoskeleton; Microtubules; MT Associated Proteins; Neurodegeneration; Neuron Markers; Neuroscience; Tangles & Tau
Citations
Publication ()
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COA
 monoclonal Antibody, clone FQS3500.jpg)
 monoclonal Antibody, clone FQS3407.jpg)
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