Magic™ Rabbit Anti-Human SMC6 Monoclonal antibody, clone 351126H21

Antibody Isotype

IgG

Clone

351126H21

Species Reactivity

Human

Immunogen

SMC6 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT789 - DMAB-CPT790
Cytometric Bead Array: 0.625-20 ng/mL

General Notes

This product (Catalog No. DMAB-CPT789) is a rabbit-derived monoclonal antibody raised against human SMC6. It has been affinity purified by Protein A. SMC6 (Structural maintenance of chromosomes protein 6) is core component of the SMC5-SMC6 complex that is involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
DMAB-CPT789 is suitable for use in Cytometric Bead Array (0.625-20 ng/mL) application.
DMAB-CPT789 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

FLJ22116; FLJ35534; hSMC6; SMC 6; SMC protein 6; SMC6; SMC6L1; structural maintenance of chromosomes 6

Entrez Gene ID

UniProt ID