Magic™ Rabbit Anti-Human PMS1 Monoclonal antibody, clone 351519I4

Antibody Isotype

IgG

Clone

351519I4

Species Reactivity

Human

Immunogen

PMS1 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1129 - DMAB-CPT1130
Cytometric Bead Array: 0.156-20 ng/mL

General Notes

This product (Catalog No. DMAB-CPT1130) is a rabbit-derived monoclonal antibody raised against human PMS1. It has been affinity purified by Protein A. PMS1 Homolog 1 is a member of the DNA mismatch repair enzymes (MMREs) which is to eliminate the mismatch of insertions and deletions as a consequence of DNA polymerase errors at DNA synthesis in eukaryotes. PMS1 and MLH1 could form a heterodimer MutLβ that belongs to MMREs (PMID:25619773). In the MMR system, the MutS complex recognizes the DNA mispairs firstly, and then the Mlh1-Pms1 and other associated proteins such as PCNA, RFC, ExoI were recruited, inducing Exonuclease 1 (Exo1)-dependent and -independent MMR pathways (PMID:24981171). Mutations in this gene cause hereditary nonpolyposis colorectal cancer(HNPCC), which is also known as Lynch syndrome. It was reported that PMS1 is a widely expressed protein and located in the nucleus. Alternative splicing allows for 4 isoforms of PMS1 protein.
DMAB-CPT1130 is suitable for use in Cytometric Bead Array (0.156-20 ng/mL) application.
DMAB-CPT1130 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

DKFZp781M0253; FLJ98259; HNPCC3; hPMS1; PMS1; PMS1 protein homolog 1; PMSL1; PMS1 postmeiotic segregation increased 1

Entrez Gene ID

UniProt ID