General Notes
This product (Catalog No. DMAB-CBAS080) is a mouse-derived monoclonal antibody raised against human MMP1. It has been affinity purified by Protein A. Matrix Metalloproteinase 1 (MMP1), also known as interstitial collagenase, is an enzyme that plays a vital role in the degradation of extracellular matrix components, particularly collagen. This protein is crucial for normal physiological processes such as tissue remodeling, wound healing, and embryogenesis. MMP1 is expressed in various tissues, including the skin, lung, and synovium, and its activity is tightly regulated by tissue inhibitors of metalloproteinases (TIMPs). Dysregulation of MMP1 has been implicated in several diseases, particularly in inflammatory conditions and cancer. Elevated levels of MMP1 are associated with rheumatoid arthritis, where it contributes to joint destruction, and with various cancers, including breast and prostate cancer, where it enhances tumor invasion and metastasis. The dual role of MMP1 in both normal tissue homeostasis and disease progression highlights its potential as a therapeutic target.
DMAB-CBAS080 is suitable for use in ELISA(Cap) application.
DMAB-CBAS080 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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