Specifications
Antibody Isotype
IgG1, kappa
Applications
Application Notes
ELISA, FACS, FuncS, Reference antibody
Each laboratory should determine an optimum working titer for use in its particular application.
Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
Opicinumab (BIIB033) is a monoclonal antibody against LINGO-1 and has potential application in acute optic neuritis and relapse multiple sclerosis.
Target
Alternative Names
Opicinumab; BIIB033; LINGO-1; leucine-rich repeat and Ig-containing Nogo receptor interacting protein-1; LERN1; LRRN6A; LINGO1; UNQ201
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Inoue, H; Lin, L; et al. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104:14430-14435(2007).
Oh, J; Calabresi, PA; et al. Emerging injectable therapies for multiple sclerosis. LANCET NEUROLOGY 12:1115-1126(2013).
COA
Certificate of Analysis