General Notes
This product (Catalog No. DMAB-CBAS075) is a mouse-derived monoclonal antibody raised against human KYNU. It has been affinity purified by Protein A. KYNU is an enzyme that plays a key role in the kynurenine pathway, which is the primary metabolic pathway for the essential amino acid tryptophan. KYNU catalyzes the conversion of kynurenine and 3-hydroxy-L-kynurenine into anthranilic acid and 3-hydroxyanthranilic acid, respectively. This pathway generates various neuroactive metabolites that have been implicated in a range of neurological and inflammatory diseases. Dysregulation of the kynurenine pathway and altered KYNU activity have been associated with several neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. KYNU expression is also increased in inflammatory bowel diseases, where it may play a role in the development and progression of chronic inflammation. Additionally, genetic variations in the KYNU gene have been linked to cardiovascular diseases and certain types of cancer.
DMAB-CBAS075 is suitable for use in ELISA(Det) application.
DMAB-CBAS075 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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