General Notes
This product (Catalog No. DMAB-CBAS068) is a mouse-derived monoclonal antibody raised against human IL33. It has been affinity purified by Protein A. IL-33 is a member of the IL-1 cytokine family and is constitutively expressed in structural and lining cells, such as endothelial and epithelial cells. It acts as an "alarmin" that is released upon cell damage or necrosis to alert the immune system. IL-33 binds to the ST2 receptor, which is expressed on various immune cells including Th2 cells, mast cells, eosinophils, and group 2 innate lymphoid cells (ILC2s). This binding activates signaling pathways like NF-κB and MAPK that drive production of type 2 cytokines like IL-5 and IL-13. The IL-33/ST2 pathway plays a critical role in the pathogenesis of allergic and Th2-mediated diseases like asthma, atopic dermatitis, and anaphylaxis. Genetic studies have linked IL-33 and ST2 to increased susceptibility to asthma.
DMAB-CBAS068 is suitable for use in ELISA(Cap) application.
DMAB-CBAS068 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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