Magic™ Rabbit Anti-Human IGFBP1 Monoclonal antibody, clone 351374I9

Antibody Isotype

IgG

Clone

351374I9

Species Reactivity

Human

Immunogen

Fusion Protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT949 - DMAB-CPT950

General Notes

This product (Catalog No. DMAB-CPT950) is a rabbit-derived monoclonal antibody raised against human IGFBP1. It has been affinity purified by Protein A. Premature rupture of fetal membranes (PROM) refers to rupture of fetal membranes before onset of labor. PROM may occur at term (>37 weeks of pregnancy) or preterm (< 37 weeks of pregnancy) when it is called preterm premature rupture of fetal membranes (PPROM). PROM is relatively common as it is suspected in 10% of pregnancies. PPROM is the most common cause for preterm delivery as it is involved in 30-40% of preterm deliveries. Preterm delivery in turn is associated with high perinatal mortality as it causes roughly 30% of all perinatal deaths. PROM is a major risk to the mother as well as to the fetus because it is also associated with an increased risk of intra-amniotic infection that may lead to neonatal sepsis. Rupture of fetal membarnes is not always associated with significant leakage of amniotic fluid and hence PROM is not always easy to diagnose and some of the historical methods do not provide adequate sensitivity or specificity. Clinical and Research Area PROM may be diagnosed using IGFBP-1 as a marker. IGFBP-1 concentration in amniotic fluid rises during preganancy and 100 to 1000 fold higher concentrations may be detected in amniotic fluid compared to human blood. Because of the high concentration even minute amounts of amniotic fluid may be detected in samples taken from vagina when PROM is suspected.
DMAB-CPT950 is suitable for use in CBA(Det), ELISA(Det) applications.
DMAB-CPT950 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

insulin-like growth factor binding protein 1; IGF binding protein 1; IGFBP-1; IGFBP1; premature rupture of fetal membranes; PROM

Entrez Gene ID

UniProt ID