Magic™ Rabbit Anti-Human HTRA2 Monoclonal antibody, clone 351507E0

Antibody Isotype

IgG

Clone

351507E0

Species Reactivity

Human

Immunogen

HTRA2 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1191 - DMAB-CPT1192
Cytometric Bead Array: 0.781-100 ng/mL

General Notes

This product (Catalog No. DMAB-CPT1192) is a rabbit-derived monoclonal antibody raised against human HTRA2. It has been affinity purified by Protein A. HTRA2(High temperature requirement protein A2) is also named as OMI, PRSS25 and belongs to the peptidase S1B family. HTRA2 normally exists in the mitochondria, can cause MMP3 activation in the cytosol under a cell stress condition, which can ultimately lead to demise of dopaminergic neuronal cells(PMID: 22265821). It inhibits mitochondrial superoxide generation, stabilizes mitochondrial membrane potential, and prevents apoptosis at baseline and in response to extracellular inducers of mitochondrial stress(PMID: 18772386). This protein has 4 isoforms produced by alternative splicing.
DMAB-CPT1192 is suitable for use in Cytometric Bead Array (0.781-100 ng/mL) application.
DMAB-CPT1192 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

HtrA serine peptidase 2; HTRA2; OMI; PARK13; PRSS25; Serine protease 25; Serine proteinase OMI

Entrez Gene ID

UniProt ID