Allele frequency data of 20 STR loci in 2000 Korean individuals
FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES
Authors: Kim, Sungmin; Park, Hyun-Chul; Kim, Jong-Sik; Nam, Younhyong; Kim, Hye Yeon; Park, Jihye; Chung, Ukhee; Lee, Jinmyung; Lim, Si-Keun; Park, Su-Jeong
To increase the discrimination power of human identification in forensic and to evaluate expanded short tandem repeat (STR) loci, we examined a Korean sample population of 2000 unrelated individuals using both GlobalFiler (TM) PCR Amplification kit and PowerPlex (R) Fusion System. Allele frequencies for the 20 STR loci (D3S1358, vWA, D16S539, CSF1PO, TPOX, D8S1179, D21S11, D18S51, D2S441, D19S433, TH01, FGA, D22S1045, D5S818, D13S317, D7S820, D10S1248, D1S1656, D12S391, and D2S1338) were calculated. Allele frequencies of the 20 STR loci would be useful for personal identification and paternity testing in forensics and as a standard reference database in Korea.
Evaluation of the genetic parameters and mutation analysis of 22 STR loci in the central Chinese Han population
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
Authors: Wang Hongdan; Kang Bing; Su Ning; He Miao; Zhang Bo; Guo Yuxin; Zhu Bofeng; Liao Shixiu; Zeng Zhaoshu
At present, the Han nationality is China's main ethnic group and also the most populous nation in the world. This is a great resource to study microsatellite mutations and for the study of ethnogeny. The aim of this study is to investigate the genetic polymorphisms and mutations of 22 autosomal STR loci in 2475 individuals from Henan province, China. DNA is amplified and genotyped using PowerPlex (TM) 24 system. The gene frequencies, forensic parameters, and the mutation rate of the 22 STR loci are analyzed. A total of 295 alleles are observed in this Henan Han population, and the allelic frequencies ranged from 0.0003 to 0.5036. In order to investigate the genetic relationships between the Henan Han and the other 14 different populations, our present data were compared with previously published data for the same 15 STR loci. The results indicated that the Henan Han had closer genetic relationships the groups including Minnan Han, Maonan, Yi and Guangdong Han groups while the South morocco population, the Moroccan population, the Malay group, and the Uigur stand away from Henan Han. Except of D2S441, D13S317, PentaE, D2S1338, D5S818, TPOX and D19S433, the mutation events are found in the other 15 STR loci. A total of 40 mutation events are observed in the 15 STR loci. The mutation rates are ranged from 0 to 4.85 x 10(-3). In this study, 39 mutations are single-step mutations, and only one at FGA comprised two steps. STR mutation is commonly existed in paternity testing, while there are no STR mutation studies of the 22 STR loci in the Henan Han population. It is of great importance in forensic individual discrimination and paternal testing.