This product (Catalog No. CABT-L1620W) is a rabbit-derived monoclonal antibody. This antibody exhibits cross-reactivity with from monkey and non-human primates. It has been affinity purified by Protein A. CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β. CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells, on some T cell receptor (TCR) γδ T cells and on NK cells. CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation. During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). CABT-L1620W is suitable for use in flow cytometry (FC) (5 μl per 10^6 cells in a 100 μl suspension) application. CABT-L1620W is supplied as a liquid formulation in PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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