Product Overview
Recombinant Human CD30 is produced by Mammalian expression system and the target gene encoding Phe19-Lys379 is expressed with a 6His tag at the C-terminus.
Molecular Weight
Mol Mass: 39.2 KDa
APMol Mass: 60-95 KDa, reducing conditions
Endotoxin
< 1 EU/μg as determined by LAL test.
Alternative Names
CD30; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8
Purity
>95% as determined by reducing SDS-PAGE
Buffer
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5 .
Storage
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 1 months.
Reconstitution
Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Introduction
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family, which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated, but not by resting, T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Keywords
CD30; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8
Citations
Have you cited DAGC-55234 in a publication?
Let us know and earn a reward for your research.
| Product Name |
Cat. No. |
Applications |
Host Species |
Datasheet |
Price |
Add to Basket |
| Product Name |
Cat. No. |
Applications |
Host Species |
Datasheet |
Price |
Add to Basket |
Simhadri, VL; Hansen, HP; et al. A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells. BIOLOGICAL CHEMISTRY 393:101-106(2012).
Oflazoglu, E; Grewal, IS; et al. Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases. THERAPEUTIC TARGETS OF THE TNF SUPERFAMILY 647:174-185(2009).
COA
Certificate of Analysis
