Magic™ Rabbit Anti-Human BMP6 Monoclonal antibody, clone 351210B2

Antibody Isotype

IgG

Clone

351210B2

Species Reactivity

Human

Immunogen

Peptide

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT733 - DMAB-CPT734
Cytometric Bead Array: 1.25-20 ng/mL

General Notes

This product (Catalog No. DMAB-CPT733) is a rabbit-derived monoclonal antibody raised against human BMP6. It has been affinity purified by Protein A. Bone morphogenetic protein 6 (BMP6) is also named as VG-1-related protein (VG-1-R, VGR-1) and VGR, and belongs to the TGF-beta family (PMID:33878365). Growth factor of the TGF-beta superfamily plays essential roles in many developmental processes including cartilage and bone formation (PMID:31019025). BMP6 participates in iron homeostasis, inhibits invasion by increasing adhesions and cell-cell type interactions and induces angiogenesis directly on vascular endothelial cells. BMP6 is coded by a tumor suppressor gene whose subexpression is related to the development and cancer progression; during neoplastic processes, methylation is the main mechanism by which gene silencing occurs (PMID:34706618). BMP6 plays an important role in the regulation of hepcidin/HAMP expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PMID:26582087). BMP6 initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B.
DMAB-CPT733 is suitable for use in Cytometric Bead Array (1.25-20 ng/mL) application.
DMAB-CPT733 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

BMP 6; BMP6; bone morphogenetic protein 6; VG 1 R; VG 1 related protein; VGR; VGR 1; VGR1

Entrez Gene ID

UniProt ID