Human beta Amyloid (1-42) Peptide

Product Overview

Amyloid β-Peptide 1-42 (human) is a 42-amino-acid fragment derived from the Amyloid Precursor Protein (APP). It has a propensity to self-aggregate into oligomers and fibrils, with the oligomeric form being the most neurotoxic. These aggregates accumulate as amyloid plaques—a hallmark of Alzheimer's disease—disrupting cellular function, causing mitochondrial dysfunction, and triggering neuronal cell death through mechanisms involving oxidative stress, calcium dysregulation, and inflammation.

Nature

Synthetic

Molecular Weight

4514.04 g/mol

Purity

>95%

Format

Lyophilized

Preservative

None

Storage

Store at -20°C

Reconstitution

DMSO

Keywords

Amyloid beta 1-42; Aβ42