Mouse Anti-Human APOC3 Monoclonal antibody, clone 6F8

Antibody Isotype

IgG1

Clone

6F8

Species Reactivity

Human

Immunogen

Human APOC3 peptide

Conjugate

Application Notes

We recommend the following antibodies for sandwich ELISA (Capture - Detection):
DMAB-CBAS009 - DMAB-CBAS010

General Notes

This product (Catalog No. DMAB-CBAS009) is a mouse-derived monoclonal antibody raised against human APOC3. It has been affinity purified by Protein A. Apolipoprotein C-III (APOC3) is a protein that plays a key role in triglyceride metabolism and cardiovascular disease risk. Studies have shown that loss-of-function mutations in the APOC3 gene are associated with lower triglyceride levels and a reduced risk of ischemic cardiovascular disease and coronary heart disease. The mechanism by which APOC3 influences cardiovascular disease risk is multifaceted. APOC3 inhibits lipoprotein lipase and hepatic lipase, which are enzymes involved in the clearance of triglyceride-rich lipoproteins. This leads to increased triglyceride levels, which is a well-established risk factor for cardiovascular disease. Additionally, APOC3 has been found to directly promote atherosclerosis by localizing to atherosclerotic lesions and inducing inflammatory and calcification pathways. Elevated APOC3 levels have also been linked to impaired pancreatic beta-cell function and the development of type 2 diabetes.
DMAB-CBAS009 is suitable for use in ELISA(Cap) application.
DMAB-CBAS009 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3; APOC3

UniProt ID