Subchronic dermal exposure to T-2 toxin produces cardiac toxicity in experimental Wistar rats
TOXICOLOGY AND INDUSTRIAL HEALTH
Authors: Chattopadhyay, Pronobesh; Islam, Johirul; Goyary, Danswrang; Agnihotri, Amit; Karmakar, Sanjev; Banerjee, Subham; Singh, Lokendra; Veer, Vijay
Abstract
Our study aimed to determine the cardiac toxicities of T-2 toxin, a representative mycotoxin that frequently contaminates maize, cereals, and other agricultural products, harvested and stored under damp and cold conditions. Dermal exposure to T-2 toxin caused severe cardiotoxicity in experimental Wistar rats. Electrocardiography studies showed the conduction abnormalities including prolongation of the QT and corrected QT interval, shortening of the PR interval, and tachycardia. Biochemical studies also reported the toxicity of T-2 toxin. T-2 toxin induced acute cardiotoxicity in rats and characterized by significant (p < 0.05) elevation of serum troponin I, creatine kinase (CK) isoenzyme MB, CK isoenzyme NAC, and lactate dehydrogenase as compared to control rats. It is concluded that cardiotoxicity effects of T-2 toxin are thought to be due to direct action on electrocardiac potentials and biochemical changes.
Structure and Properties of Lignin as an Adsorbent for Mycotoxin T-2
CHEMISTRY OF NATURAL COMPOUNDS
Authors: Kanarskaya, Z. A.; Kanarskii, A. V.; Semenov, E. I.; Karmanov, A. P.; Kocheva, L. S.; Bogdanovich, N. I.; Romanenko, K. A.
Abstract
The chemical structures of dioxane lignins isolated from several plant species were determined. Their adsorption capacity for mycotoxin T-2 was estimated. The surfaces and porous structures of the lignins were characterized. A correlation was found between the adsorption capacity and the chemical structures of the lignin preparations. It was shown that the preparation isolated from Juglans regia wood had the highest adsorption parameters.
COA
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