The HMW & Total Adiponectin ELISA is designed for the quantitative determination of HMW and total adiponectin in human serum and plasma (EDTA, heparin, and citrate) samples.
LoB: 0.015 ng/mL LoD: 0.034 ng/mL.
AdiponectIn is a 244 amino acid protein and one of several known adipocytokines secreted by the adipocyte. Adiponectin
circulates in the blood in various oligomeric complexes ranging from dimeric to "bouquet" structures of 9 or more proteins which
include HMW adiponectin (12-mer or 18-mer). Functions of adiponectin include protection against atherosclerosis, improvement
of insulin sensitivity and prevention of hepatic fibrosis. In recent years, the relationship between these physiological actions and
the multimeric structure of circulating adiponectin has attracted wide attention, and data has shown that the ratio of circulating
HMW adiponectin to total adiponectin is more informative than total adiponectin levels alone.