Anti-Human Histone H2AQ104me1 polyclonal antibody (CABT-L605R)

Rabbit anti-Human Histone H2AQ104me1 polyclonal antibody for WB, Dot

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Peptide containing human histone H2AQ104me1
Conjugate
Unconjugated

Applications


Application Notes
Recommended concentration:
WB: 1:500 - 1:1,000
Many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western Blot.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
Histone H2A; Histone H2AQ104me1; H2AQ104me1
Entrez Gene ID
UniProt ID

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


NOVEL DUAL HISTONE 3 K27M AND G34R POINT MUTATIONS IN A MIDLINE GLIOMA

NEURO-ONCOLOGY

Authors: Pan, Peter; Bale, Tejus; Miller, Alexandra; Ladanyi, Marc; Rosenblum, Marc; Haggiagi, Aya

MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes

EXPERIMENTAL CELL RESEARCH

Authors: Matsuura, Kumi; Tani, Naoki; Usuki, Shingo; Torikai-Nishikawa, Satomi; Okano, Masaki; Niwa, Hitoshi

Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA replication and DNA damage response. They form tetrameric complexes with PHD-finger proteins (Brpfs or Jades) and small non-catalytic subunits Ing4/5 and Meaf6. Although all the components of the complex are well-conserved from yeast to mammals, the function of Meaf6 and its homologs has not been elucidated in any species. Here we revealed the role of Meaf6 utilizing inducible Meaf6 KO ES cells. By elimination of Meaf6, proliferation ceased although histone acetylations were largely unaffected. In the absence of Meaf6, one of the Myst family members Myst2/Kat7 increased the ability to interact with PHD-finger proteins. This study is the first indication of the function of Meaf6, which shows it is not essential for HAT activity but modulates the assembly of the Kat7 complex.

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