Introduction
Histamine Diphosphate is a phosphate salt form of histamine, a biogenic amine involved in numerous physiological processes including immune responses, gastric acid secretion, and neurotransmission. As an agonist of histamine receptors (H₁–H₄), it is widely used in pharmacological studies to investigate receptor signaling, vascular permeability, smooth muscle contraction, and inflammatory pathways. Its high water solubility and stability make the diphosphate form suitable for biological assays, diagnostic tests, and as a positive control in allergy and mast-cell activation research. Due to its defined structure and well-characterized biological activity, histamine diphosphate serves as an important reference standard in immunology, physiology, and drug discovery.
COA
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