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Polyclonal antibody (pAb) is a mixture of antibodies produced by multiple B cell clones, which can recognize multiple different epitopes on antigen molecules. Polyclonal antibodies are usually prepared by immunizing animals (such as rabbits, sheep, and mice) with antigens containing multiple antigenic determinants to stimulate the immune system, thereby activating multiple B cell clones and producing antibodies against different antigenic epitopes. Creative Diagnostics has extensive expertise in antibody production and has original polyclonal antibody production solutions to support customer-customized polyclonal antibody production. With our extensive experience in custom antibody production, we provide high-affinity polyclonal antibody production methods to meet a variety of needs from scientific research tools to industrial production.
Stoelting Co. Stereotaxic Injector
NGC Chromatography System
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As a trusted antibody manufacturer and supplier, Creative Diagnostics has decades of industry experience and is dedicated to providing customers with personalized polyclonal antibody customization services. The company has comprehensive technical capabilities in antibody and antigen preparation, antigen modification, innovative diagnostic reagent component development, and key detection reagent research and development, covering the entire industry chain, and continues to provide strong technical support for related fields. We provide:
To meet the diverse needs of researchers for polyclonal antibody production, Creative Diagnostics provides customized and professional polyclonal antibody production services. We use advanced technologies and innovative processes to ensure that the polyclonal antibodies we produce have high reliability, accuracy and production efficiency. Our services include:
Clarify the goals, application requirements, animal species and technical feasibility, and determine the best technical path.
Develop a detailed production plan, clarify the time nodes and division of labor, and sign a cooperation agreement.
Perform immunization, detection, screening and verification, provide reports regularly, and support program optimization.
Complete serum collection, purification and functional testing to ensure the expected application.
Provide antibody samples and reports, and can expand antibody coupling, labeling and mass production services.
The graph shows the antigen concentration (ng/mL) vs. optical density at 450 nm (OD450) by indirect ELISA. The plot indicates a linear relationship with increasing antigen concentrations and high specificity between the polyclonal antibody and the target antigen. The strong response signal in the mid-concentration range indicates the high sensitivity and high binding capacity of the antibodies. The test was performed 3 times and the results were consistent in batches of antibodies.
Polyclonal antibodies (pAbs) are a heterogeneous mixture of antibodies produced by different B-cell clones in an animal. They recognize and bind to multiple epitopes on a single antigen, offering high sensitivity in assays.
The most commonly used animals include:
You typically need to provide:
The target antigen (peptide or protein)
Sequence information for peptide design (if applicable)
Desired host species
Any special requirements (e.g., purification type, titer level)
Yes, many service providers offer custom peptide synthesis, protein expression, and antigen-carrier conjugation as part of their full-service solutions.
The workflow generally includes:
Yields vary by species and protocol, but typically:
Rabbit: 50–200 mg of total IgG per collection
Goat/Sheep: Up to grams of antibody from large volumes of serum
Yes, extended immunization protocols and multiple serum collections can be arranged based on project needs.
To use our Polyclonal antibody production services, please contact Creative Diagnostics, your expert immunology service provider. From research-scale antibody production to industrial scale-up, our team is ready to support your R&D innovation.
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