Anti-Hev b1 (REF) monoclonal antibody (CABT-L2744)

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2-6.
Species Reactivity
HEV
Immunogen
Hev b1-MBP fusion protein expressed and purified from E. coli.
Conjugate
Unconjugated

Applications


Application Notes
Recommended working dilution:
ELISA: 1:32 000. Reacts as binding antibody in capture ELISA: with Hev b1 detection monoclonal antibody.
WB: 1:2000 to 1:4000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
HEV; Hepatitis E virus
UniProt ID

Citations


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References


Does community-wide water chlorination reduce hepatitis E virus infections during an outbreak? A geospatial analysis of data from an outbreak in Am Timan, Chad (2016-2017)

JOURNAL OF WATER AND HEALTH

Authors: Lenglet, Annick; Ehlkes, Lutz; Taylor, Dawn; Fesselet, Jean-Francois; Nassariman, Jean Noel; Ahamat, Abdelkhadir; Chen, Alexandra; Noh, Idriss; Moustapha, Abakar; Spina, Alexander

Hepatitis E Virus (HEV) genotype 1 and 2 infect an estimated 20 million people each year, via the faecal-oral transmission route. An urban outbreak of HEV occurred in Am Timan, Chad, between September 2016 and April 2017. As part of the outbreak response, Medecins Sans Frontieres and the Ministry of Health implemented water and hygiene interventions, including the chlorination of town water sources. We aimed to understand whether these water treatment activities had any impact on the number of HEV infections, using geospatial analysis of epidemiological and water treatment monitoring data. By conducting cluster analysis we investigated whether there were areas of particularly high and low infection risk during the outbreak and explored the reasons for this. We observed two high-risk spatial clusters of suspected cases and one high-risk cluster of confirmed cases. Our main finding was that confirmed HEV cases had a higher median number of days of exposure to unsafe water compared to suspected and non-confirmed cases (Kruskal-Wallis Chi Square: 15.5;p< 0.001). Our study confirms the mixed, but shifting, transmission routes during this outbreak. It also highlights the spatial and temporal analytical methods, which can be employed in future outbreaks to improve understanding of HEV transmission.

Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients

MICROORGANISMS

Authors: Rivero-Juarez, Antonio; Vallejo, Nicolau; Lopez-Lopez, Pedro; Isabel Diaz-Mareque, Ana; Frias, Mario; Vallejo, Aldara; Caballero-Gomez, Javier; Rodriguez-Velasco, Maria; Molina, Esther; Aguilera, Antonio

The hepatitis E virus (HEV) is the major cause of acute hepatitis of viral origin worldwide. Despite its usual course as an asymptomatic self-limited hepatitis, there are highly susceptible populations, such as those with underlying immunosuppression, which could develop chronic hepatitis. In this situation, implementation of therapy is mandatory in the sense to facilitate viral clearance. Currently, there are no specific drugs approved for HEV infection, but ribavirin (RBV), the drug of choice, is used for off-label treatment. Here, we present two cases of chronic HEV infection in transplant patients, reviewing and discussing the therapeutic approach available in the literature. The use of RBV for the treatment of an HEV infection in organ transplant patients seems to be effective. The recommendation of 12 weeks of therapy is adequate in terms of efficacy. Nevertheless, there are important issues that urgently need to be assessed, such as optimal duration of therapy and drug dosage.

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