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In 1996, the highly pathogenic avian influenza H5N1 virus was first identified in domestic waterfowl in Southern China. Since 2020-2021, the highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus has been widely circulating in wild birds globally, leading to outbreaks in poultry and other animals. In the spring of 2024, the H5N1 clade 2.3.4.4b virus was also detected in dairy cows and unpasteurized milk samples in several states across the United States, posing a significant global concern due to their severe impact on poultry populations, wildlife, and potential risks to human health.
Fig. 1 Avian influenza transmission flow from the natural reservoir (aquatic birds) to poultry, humans, and other animal species (Graziosi, G.; et al. 2024)
H5N1 is a subtype of the influenza A virus, belonging to the genus Alphainfluenzavirus in the Orthomyxoviridae family. This RNA virus has a segmented genome consisting of eight negative-sense single-stranded RNAs, abbreviated as PB2, PB1, PA, HA, NP, NA, MP, and NS. The key glycoproteins on the virus's surface are hemagglutinin (H) and neuraminidase (N). The designation "H5N1" refers to the virus having a type 5 hemagglutinin protein and a type 1 neuraminidase protein. These proteins are antigenic when the virus infects a host cell and serve as primary targets for antibodies and antiviral medications.
Influenza A virus contains multiple subtypes and strains, and often undergoes genetic drift and shift, posing a threat to the health and lives of humans and animals worldwide. Creative Diagnostics offers a wide range of high-quality antibody and antigen products related to the H5N1 influenza virus, validated for use in various assays.
<| Strain | Cat. No. | |
| IAV H5N1 (A/Dairy cattle/Texas/24-008749-003-original/2024) | DAG-WT3804 | Inquiry |
| IAV H5N1 (A/Vietnam/1194/2004) | DAG-WT3572 | Inquiry |
| IAV H5N1 (A/Chicken/Liaoning/SD00712017) | DAG-WT3573 | Inquiry |
| IAV H5N1 (A/Chicken/Henan/1212004) | DAG-WT3574 | Inquiry |
| IAV H5N1 (A/Goose/1996 Clade_0) | DAG-LY0001 | Inquiry |
| IAV H5N1 (A/Bar-Headed Goose/3/2005 Clade_2.2) | DAG-LY0002 | Inquiry |
| IAV H5N1 (A/Chicken/2/2006 Clade_7.2) | DAG-LY0003 | Inquiry |
| IAV H5N1 (A/Chicken/S4092/2011 Clade_7.2) | DAG-LY0004 | Inquiry |
| IAV H5N1 (A/Duck/70/2004 Clade_2.3.1) | DAG-LY0005 | Inquiry |
| IAV H5N1 (A/Goose/4/2012 Clade_2.3.2.1A) | DAG-LY0006 | Inquiry |
| IAV H5N1 (A/Duck/S1322/2010 Clade_2.3.2.1B) | DAG-LY0007 | Inquiry |
| IAV H5N1 (A/Duck/S12238/2013 Clade_2.3.2.1C) | DAG-LY0008 | Inquiry |
| IAV H5N1 (A/Duck/S1246/2015 Clade_2.3.2.1D) | DAG-LY0009 | Inquiry |
| IAV H5N1 (A/Chicken/SD007/2017 Clade_2.3.2.1F) | DAG-LY0010 | Inquiry |
| IAV H5N1 (A/Duck/Hunan/69/2004 Clade_2.3.3) | DAG-LY0011 | Inquiry |
| IAV H5N1 (A/Duck/1/2005 Clade_2.3.4) | DAG-LY0012 | Inquiry |
| IAV H5N1 (A/Chicken/08/2008 Clade_2.3.4) | DAG-LY0013 | Inquiry |
| IAV H5N1 (A/Chicken/07/2008 Clade_2.3.4) | DAG-LY0014 | Inquiry |
| IAV H5N1 (A/Duck/1/2006 Clade_2.3.4.2) | DAG-LY0015 | Inquiry |
| IAV H5N1 (A/Chicken/60/2005 Clade_2.3.4.2) | DAG-LY0016 | Inquiry |
| IAV H5N1 (A/Chicken/4/2013 Clade_2.3.4.4) | DAG-LY0017 | Inquiry |
| Strain | Target | Cat. No. | Expression System | |
| IAV H5N1 (A/Bar-headed Goose/Qinghai/12/2005) | HA | DAG2171 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Bar-headed goose/Qinghai/14/2008) | HA (mutated) | DAG-H10169 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Bar-headed goose/Qinghai/14/2008) | HA | DAG-H10170 | Insect cells | Inquiry |
| IAV H5N1 (A/Bar-headed goose/Qinghai/14/2008) | HA | DAG-H10177 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Bar-headed goose/Qinghai/1A/2005) | HA1 | DAG-H10222 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Bar-headed goose/Qinghai/1A/2005) | HA | DAG-H10464 | Insect cells | Inquiry |
| IAV H5N1 (A/Barn swallow/Hong Kong/D10-1161/2010) | HA1 | DAG-H10227 | Insect cells | Inquiry |
| IAV H5N1 (A/Barnswallow/Hong Kong/D10-1161/2010) | HA (mutated) | DAG-H10219 | Insect cells | Inquiry |
| IAV H5N1 (A/Barnswallow/Hong Kong/D10-1161/2010) | HA | DAG-H10225 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Bangladesh/11rs1984-30/2011) | HA1 | DAG2250 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Egypt/2253-1/2006) | HA1 | DAG-H10180 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Egypt/S3280D/2011) | HA1 | DAG2234 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Jilin/9/2004) | HA1 | DAG-H10544 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Jilin/9/2004) | HA (mutated) | DAG-H10543 | Insect cells | Inquiry |
| IAV H5N1 (A/Chicken/Jilin/9/2004) | HA | DAG-H10542 | Insect cells | Inquiry |
| IAV H5N1 (A/Chicken/India/NIV33487/2006) | HA | DAG2172 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/India/NIV33487/2006) | HA | DAG-H10432 | Insect cells | Inquiry |
| IAV H5N1 (A/Chicken/India/NIV33487/2006) | HA1 | DAG-H10199 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-016/2008) | HA | DAG2182 | Insect cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-016/2008) | HA | DAG-H10223 | Insect cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-016/2008) | HA (mutated) | DAG-H10224 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-016/2008) | HA1 | DAG-H10499 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-016/2008) | HA | DAG-H10706 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Vietnam/NCVD-700/2011) | HA1 | DAG2235 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Yamaguchi/7/2004) | HA1 | DAG-H10221 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Chicken/Yamaguchi/7/2004) | HA | DAG-H10460 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Common magpie/Hong Kong/2256/2006) | HA | DAG-H10188 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Common magpie/Hong Kong/2256/2006) | HA1 | DAG-H10189 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Common magpie/Hong Kong/5052/2007) | HA | DAG-H10455 | Insect cells | Inquiry |
| IAV H5N1 (A/Common magpie/Hong Kong/5052/2007) | HA | DAG2173 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Duck/Hong Kong/p46/1997) | HA1 | DAG-H10205 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Duck/Hong Kong/p46/1997) | HA | DAG-H10206 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Duck/Hunan/795/2002) | HA | DAG-H10186 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Duck/Hunan/795/2002) | HA1 | DAG-H10187 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Duck/Laos/3295/2006) | HA1 | DAG-H10192 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Goose/Guangdong/1/1996) | HA | DAG-H10448 | Insect cells | Inquiry |
| IAV H5N1 (A/Goose/Guangdong/1/1996) | HA | DAG-H10449 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Goose/Guiyang/337/2006) | HA1 | DAG-H10182 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Goose/Guiyang/337/2006) | HA | DAG2176 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) | HA1 | DAG-H10183 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Japanese white-eye/Hong Kong/1038/2006) | HA | DAG2177 | HEK293 cells | Inquiry |
| IAV H5N1 (A/mallard/Wisconsin/2576/2009) | HA Trimer | DAG-WT3571 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Turkey/Turkey/1/2005) | HA | DAG-H10415 | Insect cells | Inquiry |
| IAV H5N1 (A/Turkey/Turkey/1/2005) | HA | DAG-H10174 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Turkey/Turkey/1/2005) | HA (mutated) | DAG-H10173 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Whooper swan/Mongolia/244/2005) | HA (mutated) | DAG-H10197 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Whooper swan/Mongolia/244/2005) | HA1 | DAG-H10207 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Anhui/1/2005) | HA1 | DAG-H10167 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Anhui/1/2005) | HA | DAG-H10215 | Insect cells | Inquiry |
| IAV H5N1 (A/Anhui/1/2005) | HA (mutated) | DAG2168 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Anhui/1/2005) | NP | DAG-H10208 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Anhui/1/2005) | NA | DAG-H10179 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Cambodia/R0405050/2007) | HA1 | DAG-H10194 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Cambodia/R0405050/2007) | HA | DAG-H10193 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Cambodia/S1211394/2008) | HA1 | DAG-H10213 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Cambodia/S1211394/2008) | HA | DAG-H10214 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Cambodia/V0401301/2011) | HA1 | DAG2248 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/2321-NAMRU3/2007) | HA1 | DAG-H10185 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/2321-NAMRU3/2007) | HA | DAG2174 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/3300-NAMRU3/2008) | HA1 | DAG-H10217 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/3300-NAMRU3/2008) | HA | DAG2183 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/N03072/2010) | HA1 | DAG2285 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/N03072/2010) | HA | DAG2198 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/N05056/2009) | HA1 | DAG-H10191 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Egypt/N05056/2009) | HA | DAG-H10190 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hong Kong/156/1997) | HA1 | DAG2286 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hong Kong/483/1997) | HA | DAG-H10195 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hong Kong/483/1997) | HA1 | DAG2287 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hongkong/213/2003) | HA1 | DAG-H10200 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hongkong/213/2003) | HA | DAG-H10202 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hubei/1/2010) | HA1 | DAG2288 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hubei/1/2010) | HA | DAG2199 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Hubei/1/2010) | NA | DAG-H10212 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Indonesia/5/2005) | HA | DAG2210 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Indonesia/5/2005) | HA | DAG2736 | Insect cells | Inquiry |
| IAV H5N1 (A/Indonesia/5/2005) | HA (mutated) | DAG2169 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Indonesia/5/2005) | NP | DAG2320 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Indonesia/NIHRD11771/2011) | HA1 | DAG2252 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Thailand/1 (KAN-1)/2004) | NA | DAG-H10218 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Thailand/1 (KAN-1)/2004) | NP | DAG2327 | E. coli | Inquiry |
| IAV H5N1 (A/Thailand/1 (KAN-1)/2004) | M1 | DAG2307 | E. coli | Inquiry |
| IAV H5N1 (A/Vietnam/1194/2004) | HA | DAG-H10416 | Insect cells | Inquiry |
| IAV H5N1 (A/Vietnam/1194/2004) | HA1 | DAG2289 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Vietnam/1194/2004) | HA | DAG-H10176 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Vietnam/1203/2004) | HA1 | DAG1765 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Vietnam/1203/2004) | HA | DAG2170 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Vietnam/1203/2004) | HA2 | DAG2292 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Vietnam/1203/2004) | HA | DAG1608 | Insect cells | Inquiry |
| IAV H5N1 (A/Vietnam/HN31242/2007) | HA1 | DAG2574 | Insect cells | Inquiry |
| IAV H5N1 (A/Vietnam/UT31413II/2008) | HA1 | DAG-H10216 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Xinjiang/1/2006) | HA1 | DAG-H10203 | HEK293 cells | Inquiry |
| IAV H5N1 (A/Xinjiang/1/2006) | HA | DAG-H10204 | HEK293 cells | Inquiry |
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