HTLV type 1 Glycoprotein 46 (DAG4308)

HTLV type 1 Glycoprotein 46 (aa 162 - 214, 242 - 257), recombinant protein from E. coli Datasheet

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Product Overview
Recombinant HTLV-I gp46
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
Protein is > 95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.
Concentration
1 mg/ml containing 10mM Tris-HCl, pH 4.5, 100mM Sodium Phosphate, 8M urea
Storage
2-8°C short term, -20°C long term
Introduction
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Keywords
HTLV-I gp46; Glycoprotein 46; SU; Surface protein; HTLV-I gp46 antigen; Deltaretrovirus; Retroviridae; Human T-lymphotropic virus Type I; T-lymphotropic virus Type I Gp46; HTLV-1; Adult T-cell lymphoma virus type 1; Human T-lymphotropic Virus Type I Gp46

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