HTLV type 1 Glycoprotein 46

Product Overview

Recombinant HTLV-I gp46

Nature

Recombinant

Tag/Conjugate

Unconjugated

Purity

Protein is > 95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.

Concentration

1 mg/ml containing 10mM Tris-HCl, pH 4.5, 100mM Sodium Phosphate, 8M urea

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).

Keywords

HTLV-I gp46; Glycoprotein 46; SU; Surface protein; HTLV-I gp46 antigen; Deltaretrovirus; Retroviridae; Human T-lymphotropic virus Type I; T-lymphotropic virus Type I Gp46; HTLV-1; Adult T-cell lymphoma virus type 1; Human T-lymphotropic Virus Type I Gp46