The disialoganglioside GD2 is expressed on the surface of cells of most human melanomas but not on the surface of melanocytes. The specificty of this antibody towards ganglioside antigens GD2 and GD3 was demonstrated using solid-phase radioimmunoassay and enzyme-linked immunosorbent assay as well as by immunostaining on thin-layer chromatography plates using structurally characterized gangliosides. Binding of antibody to live cells was done by flow cytometry and by immunoperoxidase staining on frozen tissue sections. The binding patterns correlated with antitumor activity in antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity assays with human effector cells and complement in an release assay using cell lines derived from the same individual. This antibody was also used in monitering the levels of GD2 and GD3 in the sera of patients suffering from melanoma and healthy adults
Citations
Publication ()
Have you cited CABT-L6420 in a publication? Let us know and earn a reward for your research.
My Review for Rabbit Anti-Human GD2/GD3 monoclonal antibody, clone ME36.1
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
