Human SNCG peptide (DAG-P0470)

Specificity
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the synuclein family.
Cellular Localization
Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Procedure
None
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Function
alpha-tubulin binding; beta-tubulin binding;
Synonyms
SNCG; synuclein, gamma (breast cancer-specific protein 1); SR; BCSG1; gamma-synuclein; persyn; synoretin; breast cancer-specific gene 1 protein;

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References


Liu, CY; Guo, JP; et al. Applications of novel monoclonal antibodies specific for synuclein-gamma in evaluating its levels in sera and cancer tissues from colorectal cancer patients. CANCER LETTERS 269:148-158(2008).
Guo, J; Shou, C; et al. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. INTERNATIONAL JOURNAL OF CANCER 121:1296-1305(2007).

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