Anti-Human FSH monoclonal antibody (CABT-L2883)

Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
JID691
Species Reactivity
Human
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: IHC: 1:100 - 1:200
Positive and negative controls should be simultaneously run with unknown specimens, as there are no conclusive characteristics to suggest instability of the antibody.
The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.
The concentrated antibody requires dilution in the optimized buffer, to the recommended working dilution range (as above).
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


FSH Mouse Mab on Pituitary Gland

Target


Alternative Names
FSHB; follicle stimulating hormone, beta polypeptide; follitropin subunit beta; FSH-B; FSH-beta; follicle - stimulating hormone subunit beta
Entrez Gene ID
UniProt ID

Product Background


Pathway
Class A/1 (Rhodopsin-like receptors); Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD); Disease; FSH signaling pathway; G alpha (s) signalling events; GPCR downstream signaling; GPCR ligand binding; Glycoprotein hormones;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


A short evolutionary history of FSH-stimulated spermatogenesis

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM

Authors: Huhtaniemi, Ilpo

It is well established in various experimental models that luteinizing hormone (LH) stimulated testosterone (T) production of Leydig cells is the key endocrine stimulus of spermatogenesis. The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshr knockout mice, maintain fairly normal spermatogenesis and fertility. Furthermore, FSH treatment of male infertility has produced at best modest results. On the other hand, there are animal species (e.g. teleost fishes and the Djungarian hamster) where spermatogenesis is primarily FSH-dependent. The purpose of this article is to briefly review the gonadotrophin dependence of spermatogenesis in several model species and examine how it has shifted during evolution from FSH to LH dominance. The information may provide new insight into the role of FSH treatment of male infertility.

Identification of long non-coding RNAs in the immature and mature rat anterior pituitary

SCIENTIFIC REPORTS

Authors: Han, Dong-Xu; Sun, Xu-Lei; Fu, Yao; Wang, Chang-Jiang; Liu, Jian-Bo; Jiang, Hao; Gao, Yan; Chen, Cheng-Zhen; Yuan, Bao; Zhang, Jia-Bao

Many long non-coding RNAs (lncRNAs) have been identified in several types of human pituitary adenomas and normal anterior pituitary, some of which are involved in the pathogenesis of pituitary adenomas. However, a systematic analysis of lncRNAs expressed at different developmental stages of normal pituitary, particularly in rats, has not been performed. Therefore, we contrasted two cDNA libraries of immature (D15) and mature (D120) anterior pituitary in rat that were sequenced on an illumina HiSeq Xten platform, and a total of 29,568,806,352 clean reads were identified. Notably, 7039 lncRNA transcripts corresponded to 4442 lncRNA genes, and 1181 lncRNA transcripts were significantly differentially expressed in D15 and D120. In addition, 6839 protein-coding genes (<100 kb upstream and downstream) were the nearest neighbors of 4074 lncRNA genes. An interaction network of lncRNAs and the follicle-stimulating hormone beta-subunit (FSHb) gene was constructed using the lncRNATargets platform, and three novel lncRNAs were obtained. Furthermore, we detected the expression of the novel lncRNAs and ten highly expressed lncRNAs that were randomly selected through quantitative PCR (qPCR). The rat anterior pituitary lncRNA content identified in this study provides a more in-depth understanding of the roles of these lncRNAs in hormone and reproduction development and regulation in mammals.

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