Vitamin D3 (cholecalciferol)
Creative Diagnostics - Food & Feed Analysis
Vitamin D3 (cholecalciferol)
Vitamin D3, also known as cholecalciferol, one of active metabolites of Vitamin D, which can regulate calcium and phosphorus metabolism of the organism, induce differentiation and inhibit proliferation of various normal and cancer cells.
Vitamin D3 is mainly found in seafood, such as cod and halibut. Secondly, there is a certain amount of vitamin D3 in milk and eggs, but the content is very small. Therefore, the vitamin D3 that people consume through daily diet generally cannot meet the normal needs of the human body. Another way to supplement vitamin D3 is to convert the vitamin D in the body into vitamin D3 through sun exposure to the skin, or through dietary supplements.
Cholecalciferol as a pro-hormone will be converted to calcitriol which is important for maintaining calcium levels and promoting bone health and development. Studies have initially found that vitamin D3 supplementation can reduce the risk of death in the elderly, while vitamin D2 supplementation has no obvious beneficial effects. But for the elderly, vitamin D3 supplementation may also increase the burden on the stomach and kidneys.
Table1. Different ranges for the classification of Vitamin D3 status
| Vitamin D3 level | Reference Range (ng/mL) |
|---|---|
| Deficient | 0-10 |
| Insufficient | 10-30 |
| Sufficient | 30-100 |
| Toxicity | >100 |
In clinical diagnosis, it will be diagnosed as vitamin D3 deficiency and recommended for vitamin D3 supplementation if the level of vitamin D3 in the patient's serum is less than 10ng/mL. Various institutions have proposed different recommendations for the amount of daily intake of vitamin D. These vary according to precise definition, age, pregnancy or lactation, and the extent assumptions are made regarding skin synthesis of vitamin D. For U.S food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of Daily Value (%DV). For vitamin D labeling purposes, 100% of the Daily Value was 400 IU (10 μg), but on May 27, 2016, it was revised to 800 IU (20 μg) to bring it into agreement with the RDA.
Creative Diagnostics provide a series of Vitamin D3 antibodies and conjugates for new detection method development.
