Sulfonamides

Sulfonamides are structural analogs of para-aminobenzoic acid (PABA) and thus act as competitive antagonists in microbial cells. Sulfonamides are widely used as feed additives, mainly for fattening of calves and pigs. The presence of sulfonamide (SA) residues in foods is largely due to the raising of animals with sulfonamide antibiotics added or polluted feedstuff.  Combined with inhibitors of dihydrofolate reductase such as trimethoprim, tetroxoprim, or pyrimethamine sulfonamides are also used in veterinary medicine for the treatment of intestinal infections, mastitis, pulmonitis and other (systemic) diseases. Sulfonamide residues may therefore occur in food of animal origin such as meat and milk. It has also been suggested that the use of sulfonamides in honey may contribute to development of antibiotic-resistant pathogenic bacteria. Particularly the transmission of the carcinogenic sulfamethazine represents a threat to human health.

According to the EU law, a maximum residue limit (MRL) for all substances of the sulfonamide-group of 100 µg/kg (ppb) in muscle, fat, liver and kidney and of 100 µg/l (ppb) in milk is valid. Sensitive method has been developed for the determination of the residues of sulfonamides in animal-derived food. Creative Diagnostics provide a full list of antibodies, conjugates and test kits for the analysis of Sulfonamides antibiotics.

Key sulfonamides antibiotics analytes in our portfolio:

+ Sulfonamides
+ Apramycin
+ Sulfaclozine
+ Sulfadiazine
+ Sulfadoxine
+ Sulfamethazine
+ Sulfathiazole
+ Sulfamerazine
+ Sulfamethoxypyridazine
+ Sulfamethoxazole
+ Sulfaguanidine
+ Sulfadimethoxine
+ Sulfaquinoxaline
+ Trimethoprim
+ Sulfamonomethoxine