Nitrofurans

Creative Diagnostics - Food & Feed Analysis

Nitrofurans

Nitrofurans are synthetic broad-spectrum antibiotics. The defining structural component is a furan ring with a nitro group. Nitrofurans are frequently used in animal production due to their excellent antibacterial and pharmacokinetic properties. They have also been used as growth promoters during the production of shrimp, poultry and pigs. Nitrofurans have been detected not only in treated animals, but also in animal products, including honey.

The four major nitrofurans are furaltadone (3-amino-5-morpholinomethyl-2-oxazolidinone = AMOZ), furazolidone (3-amino-2-oxazolidinone = AOZ), nitrofurantoin (1-aminohydantoin = AHD) and nitrofurazone (semicarbazide = SEM). They have been banned in the EU for use as veterinary drugs, due to their toxic an suspected carcinogenic and mutagenic properties (Commission Regulation 1442/95). In 2003 a definitive MRPL (Minimum Required Performance Limit) was set at 1 ng/g in the EU for the above mentioned four nitrofurans in poultry and aquaculture products (Commission Decision 2003/181/EC).

Nitrofurans are rapidly metabolised, occurring in animal tissues as protein-bound metabolites. These protein-bound metabolites are stable and persistent in the body. The analysis of nitrofurans is based on the detection of the tissue bound metabolites of nitrofurans. Prior to analysis, the metabolites have to be derivatized by incubation with 2-Nitrobenzaldehyde into NP-AHD, NP-AMOZ, NP-AOZ and NP-SEM.

Key nitrofurans antibiotics analytes in our portfolio:

+ AHD
+ AMOZ
+ AOZ
+ SEM

AHD

Cat. No Product Name Product Type pdf Inquiry Add to basket
CABT-L2331 Mouse Anti-4-Nitrofurantoin metabolite 4-CPAHD monoclonal antibody, clone 4NFT Antibody Inquiry
DAGPY-2332B Nitrofurantoin [BSA] Conjugate Inquiry
DAGPY-2332O Nitrofurantoin [OVA] Conjugate Inquiry
DAGPY-2332H Nitrofurantoin [HRP] Conjugate Inquiry
DEIA-XYZ32 Nitrofurantoin (AHD) ELISA Kit ELISA Kit Inquiry

AMOZ

Cat. No Product Name Product Type pdf Inquiry Add to basket
DAGP-023B Furaltadone [BSA] Conjugate Inquiry
DAGP-023H Furaltadone [HRP] Conjugate Inquiry
DAGP-023O Furaltadone [OVA] Conjugate Inquiry
DEIA023 Furaltadone, AMOZ ELISA Kit ELISA Kit Inquiry
DISNJ19 Furaltadone Standard solution Standard Inquiry

AOZ

Cat. No Product Name Product Type pdf Inquiry Add to basket
DAGP-024B Furazolidone [BSA] Conjugate Inquiry
DAGP-024H Furazolidone [HRP] Conjugate Inquiry
DAGP-024O Furazolidone [OVA] Conjugate Inquiry
DEIA024 Furazolidone, AOZ ELISA Kit ELISA Kit Inquiry
DISNJ18 Furazolidone Standard solution Standard Inquiry

Nitrofurazone

Cat. No Product Name Product Type pdf Inquiry Add to basket
DAGP-2271B Nitrofurazone [BSA] Conjugate Inquiry
DAGP-2271H Nitrofurazone [HRP] Conjugate Inquiry
DAGP-2271O Nitrofurazone [OVA] Conjugate Inquiry
DEIA-XY2271 Nitrofurazone ELISA Kit ELISA Kit Inquiry

SEM

Cat. No Product Name Product Type pdf Inquiry Add to basket
DEIA-XYZ33 Nitrofurazone (SEM) ELISA Kit ELISA Kit Inquiry

Sodium Nifurstyrenate

Cat. No Product Name Product Type pdf Inquiry Add to basket
DAGP-0829B Sodium Nifurstyrenate [BSA] Conjugate Inquiry
DAGP-0829O Sodium Nifurstyrenate [OVA] Conjugate Inquiry
DAGP-0829BH Sodium Nifurstyrenate [HRP] Conjugate Inquiry
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