Fumonisin

Chemical formula for Fumonisin B1, C34H59NO15
Molecular Weight: 721.84 g/mol

Fumonisins are mycotoxins produced by several Fusariumspecies such as Fusarium verticillioides and Fusarium proliferatum.

Fumonisins acts as an inhibitor of ceramide synthase and prevents the biosynthesis of membranes. In humans, fumonisin is linked with esophageal cancer. In animals including horses, swine, poultry and cattle it has caused everything from heart and liver damage to impaired growth and kidney and liver cancer. Like other mycotoxins, fumonisin poses dangers to animals and humans through the food, feed and pet food supply chains. Corn and small grains such as wheat, oats and barley are the major crops affected.

U.S. FDA advisory levels for DON are as follows:

1. For : Horses and rabbits
2. Level in grain/ complete diet : 5 ppm/1 ppm
3. Commodities : Corn and corn by-products not to exceed 20% of the diet
4. For : Swine and catfish
5. Level in grain/ complete diet : 20 ppm/10 ppm
6. Commodities : Corn and corn by-products not to exceed 20% of the diet
7. For : Breeding ruminants, breeding poultry and breeding mink
8. Level in grain/ complete diet : 30 ppm/15 ppm
9. Commodities : Corn and corn by-products not to exceed 20% of the diet
10. For : Ruminants ≥ 3 months old being raised for slaughter, mink being raised for pelt
11. Level in grain/ complete diet : 60 ppm/30 ppm
12. Commodities : Corn and corn by-products not to exceed 20% of the diet
13. For : Poultry being raised for slaughter
14. Level in grain/ complete diet : 100 ppm/50 ppm
15. Commodities : Corn and corn by-products not to exceed 20% of the diet
16. For : All other species or classes of livestock and pet animals
17. Level in grain/ complete diet : 10 ppm/5 ppm
18. Commodities : Corn and corn by-products not to exceed 20% of the diet

A list of currently available CD Fumonisin products can be downloaded here.