Amikacin
Amikacin is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. Similar to other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and tRNA acceptor sites leading to the production of non-functional or toxic peptides. Other mechanisms not fully understood may confer the bactericidal effects of amikacin. Amikacin is also nephrotoxic and ototoxic.
Kanamycin
Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate.
Apramycin
Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans.
Neomycin
Neomycin (including framycetin) is intended for use in all food producing species for the treatment of bacterial gastrointestinal infections and mastitis via oral, intramammary and intramuscular administration. Maximum residue limits had previously been established for neomycin (including framycetin) for all food producing species.
Gentamicin
Gentamicin is an aminoglycoside antibiotic indicated for the treatment of a variety of bacterial infections in pigs, cattle, poultry and horses. It is composed of three major components designated C, C2 and C1a. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation).
Streptomycin
Streptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood. They are used to treat bacterial diseases in cattle, pigs, sheep and poultry.
Key aminoglycosides antibiotics analytes in our portfolio:
+ Amikacin
+ Apramycin
+ Gentamicin
+ Hygromycin B
+ Kanamycin
+ Neomycin
+ Paromomycin
+ Spectinomycin
+ Streptomycin
+ Tobramycin
