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The genus Flavivirus (family Flaviviridae) comprises more than 50 arthropod-borne viruses, including dengue virus (DENV, serotypes 1-4), Zika virus (ZIKV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and tick-borne encephalitis virus (TBEV). Collectively they cause hundreds of millions of infections each year, and their expanding geographic range - illustrated by the 2015-2016 Zika public health emergency - keeps flavivirus diagnostics high on the agenda of public health laboratories and IVD manufacturers.
The non-structural protein 1 (NS1) is a conserved, secreted flavivirus glycoprotein that accumulates to high levels in patient serum during the acute phase of infection. NS1 detection (for example, dengue NS1 antigen tests) enables diagnosis from the first days of illness, before seroconversion, and NS1-based serology complements IgM/IgG assays. Because antibody cross-reactivity among flaviviruses is strong, serology assays and antigen tests must be validated against panels spanning multiple flavivirus species - a requirement that becomes critical during outbreak response, when new assays must be developed and verified quickly.
Creative Diagnostics now offers a full-series flavivirus NS1 antigen panel covering eleven flaviviruses, produced in mammalian (HEK293/CHO), insect, and E. coli expression systems, with biotinylated and Avi-tag formats for flexible assay design. The NS1 panel is complemented by envelope (E) proteins and domain III antigens, virus-like particles (VLPs), native antigens, and inactivated quality-control materials - a one-stop raw material library for serology panel validation and public health emergency response.
Fig. 1. Flavivirus genome structure. (Rastogi M, et al. (2016))
Dengue is the most prevalent mosquito-borne viral disease worldwide, and NS1 antigen detection is a frontline diagnostic approach during the first week of illness. We provide NS1 antigens for all four serotypes in insect-cell, mammalian-cell, and E. coli formats - including a biotinylated DENV NS1 - enabling serotype-specific and pan-serotype assay development.
ZIKV emerged as a public health emergency in 2015-2016 and remains a standing requirement for arbovirus surveillance panels. Six ZIKV NS1 formats are available - insect-cell (DAGA-038), E. coli (DAGA-046), HEK293 (DAGA-047), mammalian (DAG-WT6266), and two biotinylated versions (DAGA-448; DAG-WT6882B with hFc/Avi tags) - supporting both antigen-detection assays and serology differentiation from dengue.
YFV NS1 antigens are available from four expression systems: HEK293 (DAG-WT252; DAGA-412), CHO (DAG-WT4392), and E. coli (DAG-WT253), supporting assay development for yellow fever surveillance and vaccine-response studies.
The JEV serocomplex includes JEV, WNV, KUNV, SLEV, USUV, MVEV, and WSLV - viruses with extensive serological cross-reactivity. A complete NS1 set (JEV DAGA-491; KUNV DAG-WT3838; SLEV DAGA-3071; USUV DAG-SY1; MVEV DAG-WT7981; WSLV DAG-WT7974) allows developers to build and validate serology panels that distinguish these related viruses.
Tick-borne encephalitis virus NS1 (DAG-WT7975, HEK293) completes the panel, supporting TBEV serology development alongside our TBEV glycoprotein E portfolio (DAG1587, DAG-P2788, DAG4051, and more, >95% purity per COAs).
References
| Cat. No. | Product Name | Expression System | |
| DAG-WT1348 | Recombinant JEV-E2 Antigen [His] | E. coli | Inquiry |
| DAG-WT6672 | Recombinant Japanese Encephalitis Virus E VLP | Mammalian cells | Inquiry |
| DAG-WT7111 | Inactivated Natural Japanese Encephalitis Virus Quality Control | - | Inquiry |
| DAG-WT7266 | Native Japanese encephalitis virus Antigen | Vero cells | Inquiry |
| DAG1996 | Recombinant JEV Core Protein (a.a. 1-123) [GST] | E. coli | Inquiry |
| DAGA-490 | Recombinant Japanese encephalitis virus Envelope Protein [His] | E. coli | Inquiry |
| DAGC022 | Recombinant Japanese Encephalitis Virus virus-like particles antigen | HEK293 cells | Inquiry |
| DAGA-491 | Recombinant JEV NS1 protein (>95%) [His] | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-WT6755 | Recombinant West Nile virus C Protein VLP | Mammalian cells | Inquiry |
| DAG-WT7104 | Inactivated Natural West Nile Virus (Strain NY 2001-6263) Quality Control | - | Inquiry |
| DAGA-3052 | Native West Nile Virus antigen (Strain 385-99 (New York)) | Vero cells | Inquiry |
| DAGA-3053 | Native West Nile Virus antigen (Strain B956 (Uganda)) | Vero cells | Inquiry |
| DAGC459 | Inactivated WNV Stock | - | Inquiry |
| DAG566 | Recombinant WNV Envelope protein [His] | E. coli | Inquiry |
| DAG-WT367 | Recombinant West Nile Virus Envelope VLP [His] | HEK293 cells | Inquiry |
| DAG1998 | Recombinant WNV Envelope Protein (a.a. 590-696) [His] | HEK293 cells | Inquiry |
| DAGC742 | Recombinant WNV Envelope Protein (a.a. 295-418) [His] | E. coli | Inquiry |
| DAG1999 | Recombinant WNV Envelope Protein (a.a. 291-696) [His] | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-WT3837 | Recombinant Kunjin virus Envelope protein E [His] | HEK293 cells | Inquiry |
| DAG-WT3838 | Recombinant Kunjin virus NS1 [His] | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-WT7112 | Inactivated Natural St. Louis Encephalitis Virus (Strain Parton) Quality Control | - | Inquiry |
| DAGA-3071 | Recombinant St. Louis encephalitis virus NS1 [His] | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-SY1 | Usutu virus NS1 protein (Vienna 2001) [His] | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-WT7974 | Wesselsbron virus NS1 protein | HEK293 cells | Inquiry |
| Cat. No. | Product Name | Expression System | |
| DAG-P2788 | Recombinant Tick-Borne Encephalitis Virus gE Protein (a.a. 95-229) | E. coli | Inquiry |
| DAG1586 | Recombinant TBEV gE Protein (N-terminus) [TBD] | E. coli | Inquiry |
| DAG1587 | Recombinant TBEV gE(N) | E. coli | Inquiry |
| DAG1591 | Recombinant TBEV Core Protein [His] | E. coli | Inquiry |
| DAG1592 | Recombinant TBEV NS3 Protein [His] | E. coli | Inquiry |
| DAG1593 | Recombinant TBEV preM Protein [His] | E. coli | Inquiry |
| DAG3627 | Recombinant TBEV gE Protein (a.a. 296-414) [TBD] | E. coli | Inquiry |
| DAG3628 | Recombinant TBEV gE Protein (a.a. 50-250) [TBD] | E. coli | Inquiry |
| DAG4049 | Recombinant TBEV Core Antigen | E. coli | Inquiry |
| DAG4051 | Recombinant TBEV Glycoprotein E (C-terminal) | E. coli | Inquiry |
| DAG4054 | Recombinant TBEV Non-structural Protein 3 | E. coli | Inquiry |
| DAG4696 | Native TBEV Antigen | Vero cells | Inquiry |
| DAG493 | Recombinant TBEV gE Protein [TBD] | E. coli | Inquiry |
| DAGA-604 | Recombinant Tick-borne encephalitis virus gE Protein | E. coli | Inquiry |
| DAG-WT7975 | Recombinant Tick borne encephalitis virus NS1 [His] | HEK293 cells | Inquiry |
*PLEASE note that these products are intended for research use only; not for diagnostic or clinical use.
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