The Fowl Adenovirus serotype 4 (FAdV-4) penton protein is a structural component of the viral capsid located at the vertices of the icosahedral virion, where it connects the fiber proteins to the capsid shell. The penton base, composed of pentameric subunits, plays a crucial role in mediating virus internalization by interacting with host cell integrins through conserved RGD (Arg-Gly-Asp) motifs. This interaction facilitates endocytosis of the virus into the host cell. Due to its involvement in cell entry and its conserved nature, the FAdV-4 penton protein is a significant target for studies on viral pathogenesis and vaccine development.
Keywords
Fowl Adenovirus serotype 4; FAdV-4; FAdV-4 penton
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