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Human herpesvirus 6 (HHV-6) is a prevalent pathogen associated with various clinical manifestations, ranging from the common childhood rash (rosacea) to more severe complications in immunocompromised individuals such as encephalitis, pneumonia, and transplant rejection. Accurate and timely diagnosis is crucial for effective patient management. Serological testing, especially the detection of immunoglobulin G (IgG) antibodies, remains the cornerstone for determining past infections, establishing immune status, and assisting in the diagnosis of active/recurrent infections when combined with IgM testing or PCR. The ability to detect HHV-6 IgG antibodies through reliable and efficient methods is essential for clinical and research purposes.
Figure 1. Human herpesvirus 6.
Diagnosing HHV-6 infection or reactivation can be complex. Direct methods like PCR are highly specific for detecting active viral replication, but they don't provide a complete picture of a patient's immune status or past exposure. Serological methods, which detect antibodies against the virus, are essential for this purpose. However, traditional serological assays often face challenges, including cross-reactivity with other herpesviruses like HHV-7 and cytomegalovirus (CMV), and a lack of standardized, reliable commercial kits. This is where the Enzyme-Linked Immunosorbent Assay (ELISA) emerges as a powerful tool. An ELISA is a plate-based assay designed for detecting and quantifying soluble substances such as peptides, proteins, antibodies, and hormones. By employing an ELISA for HHV-6 antibody detection, we can overcome many of the limitations of older methods. Our optimized Elisa Solution for HHV-6 IgG Antibody Detection provides a high-performance, user-friendly platform that is specifically designed to meet the demands of modern laboratories.
Technology Platform
Sample Type Compatibility
Sensitivity Profile
Kit Features
Key Features of the Product
Specifications
Intended Use
Vaccine Development & Evaluation
Immunosuppressed Patients
For patients undergoing solid organ or hematopoietic stem cell transplantation, HHV-6 reactivation is a significant risk. Routine serological monitoring using ELISA can provide a baseline of their immune status and help identify potential reactivation, especially when used in conjunction with PCR.
Encephalitis and Neurological Disorders
HHV-6 has been linked to cases of encephalitis, limbic encephalitis, and multiple sclerosis. Detecting HHV-6 IgG antibodies can provide a crucial piece of the diagnostic puzzle, particularly in patients with unexplained neurological symptoms.
| Parameter | Details |
| Product name | HHV-6 IgG ELISA Kit |
| Sample | serum or plasma |
| Intended Use | For the detection of IgG antibodies to HHV-6 in human serum isolated from venous or capillary blood. |
| Precision | The interassay variability (between tests) and the intraassay variability (within the test) were determined by testing samples with different OD values. |
| Performance Characteristics | The kit is intended for the qualitative and semiquantitative detection of anti-HHV-6 IgG antibodies in human serum and plasma. Suitable specimens are serum and plasma (heparinised) samples obtained by standard laboratory techniques. |
| General Description | The kits is intended for serological diagnosis of diseases associated with HHV–6 infection, such as exanthema subitum, acute respiratory illnesses, diarrhoea with fever and febrile seizures in infants, heterophile antibody-negative infectious mononucleosis in children, also interstitial pneumonia, encephalitis, meningitis, hepatitis and aplastic anemia in immunodeficient patients. The presence of IgG anti-HHV-6 antibody reveals the immune status of the patient. Significant rise in anti-HHV-6 IgG antibodies in paired serum samples, taken in acute and convalescent phase of the infection, is indicative of the active infection. The test does not differentiate between HHV-6 subtype A and B. |
Our Elisa Solution for HHV-6 IgG Antibody Detection is manufactured under a stringent quality management system to ensure consistency and reliability. Each lot is rigorously tested for performance, stability, and specificity. The kit components are provided in a stable, ready-to-use format with a long shelf life, minimizing waste and ensuring that you always have a high-quality product available. Furthermore, we provide comprehensive technical support to assist our users with any questions regarding the protocol, data analysis, or troubleshooting. Our commitment to quality extends beyond the product itself to ensure a seamless and successful experience for every laboratory.
High Sensitivity and Specificity
ELISA can detect low levels of antibodies and is highly specific for HHV-6 IgG, minimizing cross-reactivity with other herpesviruses
Rapid and Quantitative
ELISA provides results within a short time frame (e.g., 60 minutes) and allows for quantitative measurement of antibody levels.
Suitable for Clinical and Research Applications
ELISA is widely used in clinical laboratories and research settings for the diagnosis of HHV-6 infections
The need for a reliable, specific, and efficient method for detecting HHV-6 IgG antibodies is paramount in both clinical and research settings. Our Elisa solution for HHV-6 offers a powerful platform that addresses these needs by combining advanced antigen technology with a user-friendly and robust assay protocol. It provides an indispensable tool for diagnosing HHV-6-related conditions, monitoring at-risk patients, and advancing our understanding of this important human pathogen. By choosing our solution, laboratories can be confident in the accuracy and reliability of their results, leading to better patient care and more impactful research.
This kit uses antigens common to both variants and is designed to detect IgG antibodies against HHV-6 broadly. It does not differentiate between HHV-6A and HHV-6B.
The kit is stable for 12 months from the date of manufacture when stored at 2-8°C.
Yes. Our dedicated team of scientists provides expert technical support to help you achieve optimal assay performance.
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