Suitable for use in ELISA, LFIA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
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Background
Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline class of drugs. It is effective against a wide range of bacteria, including both Gram-positive and Gram-negative species. It is commonly used to treat respiratory tract infections, urinary tract infections, sexually transmitted infections (such as chlamydia and gonorrhea), skin and soft tissue infections, as well as certain types of atypical pneumonia. In addition to its antibacterial properties, doxycycline also has anti-inflammatory properties and is used in the treatment of inflammatory conditions such as acne and rosacea. Doxycycline is also effective against certain parasitic infections, such as malaria, and has been used as a prophylactic agent in regions where the disease is prevalent. In the context of dental care, doxycycline is used to address biofilm formation on dental abutments that can lead to peri-implant mucositis and peri-implantitis. Coating the abutment surface with doxycycline has shown promise in preventing bacterial colonization and controlling the progression of these conditions. The Anti-Doxycycline Monoclonal Antibody (CABT-L2387) is a specialized type of antibody that is specifically designed to recognize and bind to the antibiotic doxycycline. It can be integrated into diagnostic tests or analytical platforms such as immunoassays to provide accurate and sensitive detection of doxycycline in biological samples.
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References
Doxycycline as an anti-inflammatory agent: updates in dermatology
Journal of the European Academy of Dermatology and Venereology
Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its antibiotic properties, anti-inflammatory properties and good safety profile. Over the past decades, numerous studies have clarified some of the anti-inflammatory mechanisms of doxycycline. In this review article, we aimed to provide an update on recent data on the anti-inflammatory properties of doxycycline and its potential role in cutaneous inflammatory diseases. Better understanding of these mechanisms might offer the practicing clinicians a better use of this therapeutic tool. In addition, research in this field could help clarify pathogenic aspects of inflammatory dermatologic diseases responsive to this medication. Further research is needed to fully elucidate the potential of doxycycline as an anti-inflammatory agent, and the development of new topical vehicles could open ways to new therapeutic possibilities for dermatologists.
Production of monoclonal antibody against doxycycline for immunoassay of seven tetracyclines in bovine muscle and milk
The objective of this study was to produce a generic monoclonal antibody for multi-determination of the residues of tetracycline drugs in bovine muscle and milk. Two new immunogens of doxycycline were prepared that were used to produce the monoclonal antibodies. Results showed the obtained antibodies simultaneously recognized seven tetracycline drugs (doxycycline, tetracycline, chlortetracycline, oxytetracycline, minocycline, methacycline, demeclocycline). The obtained antibodies and three coating antigens were arranged into six combinations to optimize the reagents combination. After comparison of the performances of these combinations, a heterologous indirect competitive ELISA was then used to determine the seven tetracyclines in bovine muscle and milk. The crossreactivities to the seven analytes were in the range of 47%-102% and the limits of detection were in the range of 1.5-6.9 ng/mL depending on the compound. The recoveries of the seven drugs from fortified blank samples were in the range of 75.3%-106.8% with coefficients of variation lower than 10.9%. Therefore, this method could be used as a multi-analytes screen tool for routine monitoring of the residues of these tetracycline drugs in bovine muscle and milk.
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