Description
Bacterial lipopolysaccharide (LPS) was demonstrated to have the capacity in mice to enhance the response to soluble bovine serum albumin (BSA) and to interfere with the induction of tolerance to human 7-globulin (HGG). Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules possess a broad spectrum of immunologic activities. immune responses. LPS is a mitogen for B lymphocytes, it is a powerful adjuvant of antibody formation, and as an antigen it is highly immunogenic in that extremely small amounts will elicit a specific antibody response in
vivo. LPS may act as an adjuvant because of its ability to induce mitogenesis in B cells.
Structually, lipid A molecules are composed of two glucosamine unites with varied, species dependent, fatty acyl chain number and identity and degree of phosphorylation.
Diphosphoryl Lipid A (MPLA) is prepared from E. coli K12 D31m4. Lipid A, a disaccharide with fatty acid side chains, recognized by TLR4 receptors, is the component responsible for the endotoxic activity of LPS.
Related vaccines: Brucella ovis Microparticle Subunit Vaccine (Brucella spp.)
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