Cynomolgus ACE2 Protein [His] (DAGC229)

Recombinant Cynomolgus ACE2 Protein from HEK293 Cells [His]

Product Overview
Cynomolgus ACE2, His Tag is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Thr 741 (Accession # A0A2K5X283-1). This protein carries a polyhistidine tag at the N-terminus.
Nature
Recombinant
Predicted N terminal
His
Tag/Conjugate
His
Molecular Weight
The protein has a calculated MW of 85.7 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per ug by the LAL method.
Alternative Names
ACE2; ACHE; ACE-2
Procedure
None
Purity
>95% as determined by SDS-PAGE.
Format
Liquid
Size
50ug, 1mg
Buffer
Delivered as bulk protein in a 0.2 um filtered solution of 50 mM Tris, 150 mM NaCl, Arginine, pH7.5 with glycerol as protectant.
Preservative
None
Storage
Store at -70°C or lower upon receipt.
Ship
Shipped with dry ice
Introduction
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Keywords
ACE2; ACHE; ACE-2

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References


He, YX; Zhou, YS; et al. Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324:773-781(2004).
Zhang, Y; Zheng, N; et al. Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization. COMPUTATIONAL BIOLOGY AND CHEMISTRY 31:129-133(2007).

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