Citreoviridin [HRP]

Target

Citreoviridin

Specificity

N/A

Nature

Synthetic

Tag/Conjugate

HRP

Alternative Names

Citreoviridin; CIT; 25425-12-1; 2,5-anhydro-1,6-dideoxy-2-C-[(8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1E,3E,5E,7E-octatetraen-1-yl]-4-C-methyl-D-iditol

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements.

Buffer

0.01M PBS, pH7.4

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Ship

Wet ice

Introduction

Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system. It inhibits soluble ATPase (KD = 4.1 μM), ADP stimulated respiration in isolated rat liver mitochondria (KD = 0.15 μM), and ATP-driven reduction of NAD+ by succinate (KD = 2 μM). Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.

Keywords

Citreoviridin;CIT;25425-12-1;2,5-anhydro-1,6-dideoxy-2-C-[(8-(4-methoxy-5-methyl-2-oxo-2Hpyran-6-yl)-2-methyl-1E,3E,5E,7E-octatetraen-1-yl]-4-C-methyl-D-iditol