Anti-Rat CD4 Monoclonal antibody (CABT-L4534) Functional Grade

Mouse Anti-Rat CD4 Monoclonal antibody for FC

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a, κ
Clone
OX-38
Species Reactivity
Rat
Immunogen
Rat thymocyte glycoproteins
Conjugate
Functional Grade

Target


Alternative Names
CD4; T-cell surface glycoprotein CD4; cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3

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Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Mouse IgG2a kappa Isotype Control DAGIC802 FC ICFC WB IP ICC IF IHC FA Mouse PDF Inquiry

References


Intralesional injection of biosimilar rituximab in recalcitrant mucocutaneous lesions of patients with pemphigus vulgaris: A pilot study

DERMATOLOGIC THERAPY

Authors: Mazloom, Ebrahim; Daneshpazhooh, Maryam; Shokouhi Shoormasti, Raheleh; Balighi, Kamran; Mahmoudi, Hamidreza; Moradi Ketisari, Masoud; Eslami Faresani, Vahid; Ghandi, Narges

The efficacy of intravenous rituximab (RTX) in patients with pemphigus have been shown in the previous studies. The study aimed to investigate the effectiveness of intralesional injection of RTX in the healing of pemphigus lesions, with lower doses and probable better safety profile than intravenous RTX. Eleven Pemphigus patients with recalcitrant lesions received two intralesional injections of biosimilar RTX, 5 mg/cm(2). During 6 months follow-up, Pemphigus Disease Area Index, the patients' satisfaction, quality of life, the disease activity, the number and size of lesions, the anti-desmoglein (Dsg) 1 and 3 antibodies and the count of CD4+ and CD19+ cells were assessed. All patients were in partial remission on therapy. The absolute count of CD19+ B cells showed a statistically significant decline (P = .006). The percentage of CD4 + T lymphocytes increased 2 weeks after injection and decreased 2 weeks later (P = .01). The average number and size of lesions decreased. The concentration of anti-Dsg 3 antibody decreased insignificantly during the study. The severe pain during the injection was considered as the main complication. At the end of the study, two patients were in complete remission on therapy, and the other nine remained in partial remission on therapy. Few side effects resulting from intralesional injection of RTX and enhanced quality of life of the patients were considered as the valuable achievements of this study. The results showed that although a low dose of RTX leads to a significant decrease of CD19+ B lymphocytes, it did not show parallel clinical effectiveness.

Carbohydrate Sulfotransferase 4 Inhibits the Progression of Hepatitis B Virus-Related Hepatocellular Carcinoma and Is a Potential Prognostic Marker in Several Tumors

FRONTIERS IN ONCOLOGY

Authors: Zhang, Longshan; Fan, Yao; Wang, Xiaoqing; Yang, Mi; Wu, XiXi; Huang, Weiqiang; Lan, Jin; Liao, Liwei; Huang, Wenqi; Yuan, Lu; Pan, Hua; Wu, Yuting; Chen, Longhua; Guan, Jian

Carbohydrate sulfotransferase 4 (CHST4) plays an important role in lymphocyte homing and is abnormally expressed in several cancer types; however, its precise function in tumor development and progression is unknown. Here we confirm that CHST4 is aberrantly expressed in various tumor subtypes. In particular, we found that CHST4 expression was downregulated in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) tumors compared to paired normal tissue. We also showed that CHST4 overexpression inhibited the proliferation and metastasis of HCC cells in vitro. Clinically, CHST4 was identified as an independent prognostic factor for HBV-HCC patients. We further illuminated the anti-tumor role and mechanism of CHST4 in HBV-HCC by constructing a FENDRR-miR-10b-5p-CHST4 competing endogenous RNA network. We found that downregulation of CHST4 expression may promote HBV expression and regulate ribonucleoprotein complex biogenesis to promote malignant behaviors in HBV-HCC. CHST4 may also recruit CD4+ T cells, macrophages, dendritic cells, and neutrophils into the tumor microenvironment to inhibit the progression of HBV-HCC. Overall, our findings suggest that CHST4 acts as a tumor suppressor in HCC-HBV and represents a potential diagnostic and therapeutic target.

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