Species Reactivity
Canine
Intended Use
This ELISA kit is for quantification of CD200 in Canine samples. This is a shorter ELISA assay that reduces time to 50% compared to the conventional method, and the entire assay only takes 3 hours.
Storage
Store the kit at 4°C. The kit can be used in 6 months.
Precision
Intra-Assay %CV: 6;
Inter-Assay %CV: 9
Detection Range
125-8,000 pg/ml
General Description
Cluster of Differentiation 200 (CD200) also known as OX-2 membrane glycoprotein and is encoded by the CD200 gene. [1] CD200 is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. CD200 interacts with its receptor CD200R to transmit signals and aberrant expression of CD200/CD200R might play a role in psoriasis vulgaris pathophysiology and disease severity. [2] CD200 is overexpressed in neuroblastoma and regulates tumor immune microenvironment. [3] CD200 down regulates macrophage lineage and basophil function. [4] [5]
Citations
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Talebian, F; Bai, XF; et al. The role of tumor expression of CD200 in tumor formation, metastasis and susceptibility to T lymphocyte adoptive transfer therapy. ONCOIMMUNOLOGY 1:971-973(2012).
Gorczynski, RM; Lee, L; et al. Augmented induction of CD4(+)CD25(+) Treg using monoclonal antibodies to CD200R. TRANSPLANTATION 79:1180-1183(2005).
COA
Certificate of Analysis
