REL blocking peptide (CDBP0878)

Product Overview
c-Rel peptide (C-term)
Target
c-Rel
Nature
Synthetic
Tag/Conjugate
Unconjugated
Procedure
None
Format
Liquid
Concentration
1 mg/ml
Size
50 μg
Buffer
Antiserum containing 0.01% sodium azide
Preservative
0.01% Sodium Azide
Storage
Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.
UniProt ID
Antigen Description
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Function
protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
Synonyms
REL; v-rel avian reticuloendotheliosis viral oncogene homolog; C-Rel; proto-oncogene c-Rel; oncogene REL, avian reticuloendotheliosis;

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References


Bioengineered immune therapeutics targeting O-GlcNAcylated NF-kappaB c-Rel to treat autoimmune diabetes

EUROPEAN JOURNAL OF IMMUNOLOGY

Authors: Ramakrishnan, P.; Pokorski, J.; Centore, J.; de Jesus, T.; Church, D.

Mass Spectra of New Heterocycles: XXI. Study of Alkyl [(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetates by Electron and Chemical Ionization Mass Spectrometry

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Authors: Klyba, L., V; Nedolya, N. A.; Sanzheeva, E. R.; Tarasova, O. A.

The fragmentation of previously inaccessible alkyl [(5-amino-1H-pyrrol-2-yl)sulfanyl]acetates under electron (70 eV) and chemical (reactant gas methane) ionization conditions was studied for the first time. Under electron ionization, all the studied compounds form a molecular ion (I(rel)7-100%), the main primary fragmentation pathway of which is associated with the C-S bond cleavage in the sulfanyl group and elimination of the ester fragment ((ROCOCH2)-O-4) in the form of a radical. The chemical ionization of alkyl [(5-amino-1H-pyrrol-2-yl)sulfanyl]acetates is characterized by protonation, recharging, and electrophilic addition. The base peak belongs to an [M+ H](+)ion. Chemical ionization is accompanied by the elimination of an R(4)OCOCH(2)radical from theM(+center dot)and [M+ Et](+)ions and an (ROCOCHS)-O-4 molecule from theM(+center dot)and [M+ H](+)ions.

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