REL blocking peptide

Name: REL blocking peptide
SKU: CDBP0878
Rating: 5 (1 reviews)

Synthetic REL blocking peptide for BL

COA

SDS

Datasheet

Summary

Product Overview

c-Rel peptide (C-term)

Target

c-Rel

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

1 mg/ml

Buffer

Antiserum containing 0.01% sodium azide

Preservative

0.01% Sodium Azide

Storage

Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.

Entrez Gene ID

5966

Antigen Description

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Function

protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

Synonyms

REL; v-rel avian reticuloendotheliosis viral oncogene homolog; C-Rel; proto-oncogene c-Rel; oncogene REL, avian reticuloendotheliosis;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Bioengineered immune therapeutics targeting O-GlcNAcylated NF-kappaB c-Rel to treat autoimmune diabetes

EUROPEAN JOURNAL OF IMMUNOLOGY

Authors: Ramakrishnan, P.; Pokorski, J.; Centore, J.; de Jesus, T.; Church, D.

Abstract

Mass Spectra of New Heterocycles: XXI. Study of Alkyl [(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetates by Electron and Chemical Ionization Mass Spectrometry

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Authors: Klyba, L., V; Nedolya, N. A.; Sanzheeva, E. R.; Tarasova, O. A.

Abstract

The fragmentation of previously inaccessible alkyl [(5-amino-1H-pyrrol-2-yl)sulfanyl]acetates under electron (70 eV) and chemical (reactant gas methane) ionization conditions was studied for the first time. Under electron ionization, all the studied compounds form a molecular ion (I(rel)7-100%), the main primary fragmentation pathway of which is associated with the C-S bond cleavage in the sulfanyl group and elimination of the ester fragment ((ROCOCH2)-O-4) in the form of a radical. The chemical ionization of alkyl [(5-amino-1H-pyrrol-2-yl)sulfanyl]acetates is characterized by protonation, recharging, and electrophilic addition. The base peak belongs to an [M+ H](+)ion. Chemical ionization is accompanied by the elimination of an R(4)OCOCH(2)radical from theM(+center dot)and [M+ Et](+)ions and an (ROCOCHS)-O-4 molecule from theM(+center dot)and [M+ H](+)ions.