BKV VP1 Antibodies

Overview

Details about BKV VP1

The primary capsid protein of BKV is VP1 which presents the following structural features and functional characteristics.

Feature	Details
Structural Features	VP1 forms an icosahedral structure with T=7 symmetry, 50 nm in diameter. The capsid is made up of 72 pentamers linked by disulfide bonds and combined with VP2 or VP3 proteins.
Receptor Binding	VP1 binds to glycosphingolipids with terminal α2-8-linked sialic acids (e.g., GT1b and GD1b) on cell surfaces to facilitate viral particle attachment.
Viral Entry	The attachment of VP1 triggers viral particle internalization mainly by caveolin-mediated endocytosis, followed by transport to the endoplasmic reticulum.
Viral Replication	VP1 binds to replicated genomic DNA in the nucleus and participates in nucleosome arrangement around viral DNA during later stages of infection.
Immunogenicity	VP1 triggers a strong immune response. Neutralizing antibodies target VP1, helping the virus evade host immune detection.
Serotyping	Four BKV serotypes (I-IV) based on genetic analysis of VP1 sequence, differentiated by variations in the BC loop region. The virus cannot survive without VP1, as changes in the VP1 ORF lead to a non-viable virus. VP1 is critical for viral entry, replication, and virion assembly.

Creative Diagnostics takes pleasure in presenting our top-grade BKV VP1 Antibodies which were carefully developed to identify and analyze the BK virus (BKV) VP1 protein. Advanced manufacturing techniques produce these antibodies which provide outstanding performance and reliability to serve as the ideal solution for numerous research applications.

BKPyV-infected RPTECs treated with DMSO, 20 mM DFX, 20 mM DFP, and 20 mM DFO from 2 hpi were fixed and stained with anti-VP1 antibody (red) (Sun J, 2021)

Anti-BKV VP1 Monoclonal antibody

Get a Quote

Discover more:

Mouse Anti-BKV VP1 Monoclonal antibody, clone 4C3

Rabbit Anti-BKV VP1 Monoclonal Antibody, clone NEG447A

Human Anti-BKV VP1 Monoclonal Antibody, clone NEG447A

Additionally, you can Submit an Online Inquiry on the product details page by scrolling to the bottom to request dedicated support when you need specific product details or further information!

Why Choose Our BKV VP1 Antibodies?

Unmatched Specificity: We carefully choose and thoroughly validate each antibody to guarantee precise targeting of the BKV VP1 protein which delivers dependable results.
Superior Affinity: Our antibodies exhibit high binding affinity which allows for enhanced detection sensitivity that produces precise and accurate measurements.
Versatile Research Tools: Our antibodies are engineered to accommodate a broad spectrum of experimental requirements in ELISA and immunocytochemistry (ICC/IF) alongside other assay types.
Quality You Can Trust: Our rigorous quality control tests every batch to ensure reliable performance and dependable outcomes.

Our selection of labeled antibodies includes our catalog products which come with numerous fluorescent dyes and labels such as HRP, biotin, ALP, DyLight® Fluor dyes, and R-phycoerythrin (R-PE). Customers can purchase IgG antibodies in quantities that range from a minimum of 100 μg to a maximum of 1 g. We subject all of our antibodies to rigorous testing processes to achieve maximum specificity while maintaining high affinity and consistency in different experimental conditions.

Discover the Multiple Applications of BKV VP1 Antibodies

Our BKV VP1 Antibodies serve as essential tools across multiple research disciplines.

Viral Research
Our BKV VP1 Antibodies enable researchers to understand the infection methods BKV uses, how it reproduces within host cells and the immune system's response to it.
Drug & Vaccine Development
Pursue the advancement of both therapeutic measures and vaccines which are specifically designed to fight the BK virus.
Understanding what BKV represents should be our initial step.
The BK virus (BKV) represents a small double-stranded DNA virus that lacks an envelope and is part of the Polyomaviridae family. BKV infects humans early in their lives and maintains a latent state in healthy people. The BK virus becomes active again in immunosuppressed patients including kidney transplant recipients and this reactivation leads to severe conditions like PVAN.

BKV has a circular 5,000 bp genome that encodes six proteins: The virus's genome produces six proteins which include three capsid polypeptides (VP1, VP2 and VP3) as well as three non-structural proteins (the large T antigen (TAg), the small T antigen (tAg), and agnoprotein). The virus establishes long-term infection in the renal tract resulting in asymptomatic reactivation and periodic low-level urinary shedding detected in 5 to 10% of healthy people.

Important Notes

Research Use Only: The products from our company are designed exclusively for research and laboratory applications and must not be employed for diagnostic or therapeutic purposes nor for household uses or any other applications.
Ingredients Information: The product contains animal-derived antibodies which are usually suspended in buffered solutions. Bovine serum albumin (BSA) and chemical preservatives may be components of some antibodies. Individual product datasheets provide all specific information.

Our Antibodies are ready for laboratory use to advance research and improve understanding of diseases associated with BKV VP1 protein and help you reach exceptional research results. Not sure about how to choose the right solution for your project? Contact Us

References

Kant S, Dasgupta A, Bagnasco S, Brennan DC. BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review. Viruses. 2022;14(8):1616.
Sullivan CS, Pipas JM. T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis. Microbiol Mol Biol Rev. 2002;66(2):179-202.
Sun J, Shi Y, Shi H, Hou Y, Hu C, Zeng Y, Wu G, Zhu T. Intracellular Low Iron Exerts Anti-BK Polyomavirus Effect by Inhibiting the Protein Synthesis of Exogenous Genes. Microbiol Spectr. 2021;9:e01094-21.

Reagent Solutions

BKV ELISA Kits

Target	Cat. No.	Product Name	Size	Species	Application	Detection Sample
BKV	DEIASL161	Anti-polyomavirus BK (BKV) IgG ELISA Kit	96T		Semi-quantitative	serum and plasma	Inquiry

BKV Antibodies

Target	Cat. No.	Product Name	Host	Isotype	Application
BKV VP1	CABT-NS1131	Rabbit Anti-BKV VP1 Monoclonal Antibody, clone NEG447A	Rabbit	IgG	ELISA	Inquiry
	CABT-NS1132	Human Anti-BKV VP1 Monoclonal Antibody, clone NEG447A	Human	IgG1	ELISA	Inquiry
	CABT-CS613	Mouse Anti-BKV VP1 Monoclonal antibody, clone 4C3	Mouse	IgG1 Kappa	WB, IHC, ELISA	Inquiry
Polyomavirus early antigen	DMABT-Z60972	Anti-Polyomavirus Early Antigen Monoclonal antibody, Clone RaE	Rat	IgG2b	WB, IP, ICC, IF	Inquiry
Polyomavirus Large T antigen	DMABT-Z59919	Anti-Polyomavirus Large T antigen Monoclonal antibody, Clone RaLV	Rat	IgG2b	WB, IP, ICC, IF	Inquiry
Polyomavirus Medium T	DMABT-Z60955	Anti-Polyomavirus Medium T Monoclonal antibody, Clone RaOV	Rat	IgG2b	IP, ICC, IF, WB	Inquiry
Polyomavirus PyMT	DMAB7134	Anti-Polyomavirus PyMT Monoclonal antibody, Clone Hmv-Hmv	Mouse	IgG1	IF, WB, IP	Inquiry

BKV Antigens

Target	Cat. No.	Product Name	Expression System	Tag/Conjugate	Application
Polyomavirus Major Capsid VP1	DAG-P2867	Polyomavirus Major Capsid VP1 (full length)	S. cerevisiae	KLH	ELISA, WB, SDS-PAGE	Inquiry
Polyomavirus Major Capsid VP1	DAG-P2869	Polyomavirus Major Capsid VP1 (full length)	S. cerevisiae	KLH	ELISA, WB, SDS-PAGE	Inquiry

Inquiry Basket

Loading ......

Inquiry