Molecular Weight
42.9 kDa
Purity
> 95% as determined by HPLC
Buffer
Lyophilized from 0.22um filtered solution in PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization
Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week
Reconstitution
Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Introduction
Monocyte chemoattractant protein-1 (MCP-1) plays a pivotal role in the development of the inflammatory response.1 MCP-1 expression increases at injury sites to direct macrophage recruitment. Mechanistically, MCP-1 binds to the inducible C-C chemokine receptor 2 (CCR2) to promote chemotaxis. There are 2 known subtypes of CCR2, CCR2a and CCR2b. CCR2b is 5-fold more potent than CCR2a in inducing macrophage chemotaxis.
Keywords
CCR2b; Chemokine receptor CCR2b
Citations
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Chen, AR; Mumick, S; et al. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. OBESITY RESEARCH 13:1311-1320(2005).
Fujita, K; Ewing, CM; et al. Monocyte Chemotactic Protein-1 (MCP-1/CCL2) Is Associated With Prostatic Growth Dysregulation and Benign Prostatic Hyperplasia. PROSTATE 70:473-481(2010).
COA
Certificate of Analysis
