Anti-XPO1 Polyclonal Antibody (CABT-L2193) Knockout Validated

Rabbit Anti-Human XPo1 (Thr917~Asp1071) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Pig
Immunogen
Recombinant fragment corresponding to human XPO1 (Thr917~Asp1071)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


K562 human chronic myelogenous leukemia cell line was stained with rabbit Anti-human XPo1 Polyclonal Antibody or Isotype control antibody, followed by APC-conjugated Anti-rabbit IgG Secondary Antibody .
Knockout Varification: Lane 1: Wild-type Hela cell lysate. Lane 2: XPo1 knockout Hela cell lysate. Predicted MW: 123kd, Observed MW: 110kd
Figure. Western Blot. Sample. Lane1: Human Hela Cells; Lane2: Human K562 Cells; Lane3: Human Lung Tissue; Lane4: Porcine Intestine Tissue.

Target


Alternative Names
Exp1; CRM1 Homolog,Yeast; Chromosome region maintenance 1 protein homolog
Entrez Gene ID
UniProt ID

Product Background


Pathway
Canonical NF-kappaB pathway; Cell Cycle; Cell Cycle, Mitotic; Cyclin A/B1 associated events during G2/M transition; Disease; Downregulation of TGF-beta receptor signaling; Epstein-Barr virus infection; Export of Viral Ribonucleoproteins from Nucleus;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Noguchi, E; Saitoh, YH; et al. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1. JOURNAL OF BIOCHEMISTRY 125:574-585(1999).

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